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A neutrophil response linked to tumor control in immunotherapy.
Gungabeesoon J, Gort-Freitas NA, Kiss M, Bolli E, Messemaker M, Siwicki M, Hicham M, Bill R, Koch P, Cianciaruso C, Duval F, Pfirschke C, Mazzola M, Peters S, Homicsko K, Garris C, Weissleder R, Klein AM, Pittet MJ. Gungabeesoon J, et al. Among authors: pfirschke c. Cell. 2023 Mar 30;186(7):1448-1464.e20. doi: 10.1016/j.cell.2023.02.032. Cell. 2023. PMID: 37001504 Free PMC article.
Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils.
Pfirschke C, Engblom C, Gungabeesoon J, Lin Y, Rickelt S, Zilionis R, Messemaker M, Siwicki M, Gerhard GM, Kohl A, Meylan E, Weissleder R, Klein AM, Pittet MJ. Pfirschke C, et al. Cell Rep. 2020 Sep 22;32(12):108164. doi: 10.1016/j.celrep.2020.108164. Cell Rep. 2020. PMID: 32966785 Free PMC article.
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy.
Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ. Siwicki M, et al. Among authors: pfirschke c. Sci Immunol. 2021 Jul 2;6(61):eabi7083. doi: 10.1126/sciimmunol.abi7083. Sci Immunol. 2021. PMID: 34215680 Free PMC article.
Common TLR5 mutations control cancer progression.
Pfirschke C, Garris C, Pittet MJ. Pfirschke C, et al. Cancer Cell. 2015 Jan 12;27(1):1-3. doi: 10.1016/j.ccell.2014.12.008. Cancer Cell. 2015. PMID: 25584886 Free article.
The role of myeloid cells in cancer therapies.
Engblom C, Pfirschke C, Pittet MJ. Engblom C, et al. Among authors: pfirschke c. Nat Rev Cancer. 2016 Jul;16(7):447-62. doi: 10.1038/nrc.2016.54. Nat Rev Cancer. 2016. PMID: 27339708 Review.
PF4 Promotes Platelet Production and Lung Cancer Growth.
Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, Engblom C, Mino-Kenudson M, Hynes RO, Weissleder R, Pittet MJ. Pucci F, et al. Among authors: pfirschke c. Cell Rep. 2016 Nov 8;17(7):1764-1772. doi: 10.1016/j.celrep.2016.10.031. Cell Rep. 2016. PMID: 27829148 Free PMC article.
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.
Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. Engblom C, et al. Among authors: pfirschke c. Science. 2017 Dec 1;358(6367):eaal5081. doi: 10.1126/science.aal5081. Science. 2017. PMID: 29191879 Free PMC article.
Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.
Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ. Garris CS, et al. Among authors: pfirschke c. Immunity. 2018 Dec 18;49(6):1148-1161.e7. doi: 10.1016/j.immuni.2018.09.024. Epub 2018 Dec 11. Immunity. 2018. PMID: 30552023 Free PMC article.
34 results