Pfenninger A - Search Results

1

Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization.

Matter H, Zoller G, Herling AW, Sanchez-Arias JA, Philippo C, Namane C, Kohlmann M, Pfenninger A, Voss MD. Matter H, et al. Among authors: pfenninger a. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1817-22. doi: 10.1016/j.bmcl.2013.01.030. Epub 2013 Jan 22. Bioorg Med Chem Lett. 2013. PMID: 23395660

2

Discovery and pharmacological characterization of SAR707 as novel and selective small molecule inhibitor of stearoyl-CoA desaturase (SCD1).

Voss MD, Zoller G, Matter H, Herling AW, Biemer-Daub G, Pfenninger A, Haag-Diergarten S, Keil S, Kohlmann M, Schmidts HL. Voss MD, et al. Among authors: pfenninger a. Eur J Pharmacol. 2013 May 5;707(1-3):140-6. doi: 10.1016/j.ejphar.2013.03.019. Epub 2013 Mar 22. Eur J Pharmacol. 2013. PMID: 23524088

3

Stimulation of fat oxidation, but no sustained reduction of hepatic lipids by prolonged pharmacological inhibition of acetyl CoA carboxylase.

Glien M, Haschke G, Schroeter K, Pfenninger A, Zoller G, Keil S, Müller M, Herling AW, Schmoll D. Glien M, et al. Among authors: pfenninger a. Horm Metab Res. 2011 Aug;43(9):601-6. doi: 10.1055/s-0031-1283138. Epub 2011 Aug 5. Horm Metab Res. 2011. PMID: 21823054

4

Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations.

Evers A, Bossart M, Pfeiffer-Marek S, Elvert R, Schreuder H, Kurz M, Stengelin S, Lorenz M, Herling A, Konkar A, Lukasczyk U, Pfenninger A, Lorenz K, Haack T, Kadereit D, Wagner M. Evers A, et al. Among authors: pfenninger a. J Med Chem. 2018 Jul 12;61(13):5580-5593. doi: 10.1021/acs.jmedchem.8b00292. Epub 2018 Jun 25. J Med Chem. 2018. PMID: 29879354

5

Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane.

Kramer W, Girbig F, Corsiero D, Pfenninger A, Frick W, Jähne G, Rhein M, Wendler W, Lottspeich F, Hochleitner EO, Orsó E, Schmitz G. Kramer W, et al. Among authors: pfenninger a. J Biol Chem. 2005 Jan 14;280(2):1306-20. doi: 10.1074/jbc.M406309200. Epub 2004 Oct 19. J Biol Chem. 2005. PMID: 15494415 Free article.

6

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach.

Raichur S, Brunner B, Bielohuby M, Hansen G, Pfenninger A, Wang B, Bruning JC, Larsen PJ, Tennagels N. Raichur S, et al. Among authors: pfenninger a. Mol Metab. 2019 Mar;21:36-50. doi: 10.1016/j.molmet.2018.12.008. Epub 2019 Jan 2. Mol Metab. 2019. PMID: 30655217 Free PMC article.

7

Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice.

Pflimlin E, Bielohuby M, Korn M, Breitschopf K, Löhn M, Wohlfart P, Konkar A, Podeschwa M, Bärenz F, Pfenninger A, Schwahn U, Opatz T, Reimann M, Petry S, Tennagels N. Pflimlin E, et al. Among authors: pfenninger a. Cell Metab. 2018 Aug 7;28(2):217-227.e13. doi: 10.1016/j.cmet.2018.05.028. Epub 2018 Jun 21. Cell Metab. 2018. PMID: 29937376 Free article.

8

A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.

Kannt A, Rajagopal S, Kadnur SV, Suresh J, Bhamidipati RK, Swaminathan S, Hallur MS, Kristam R, Elvert R, Czech J, Pfenninger A, Rudolph C, Schreuder H, Chandrasekar DV, Mane VS, Birudukota S, Shaik S, Zope BR, Burri RR, Anand NN, Thakur MK, Singh M, Parveen R, Kandan S, Mullangi R, Yura T, Gosu R, Ruf S, Dhakshinamoorthy S. Kannt A, et al. Among authors: pfenninger a. Sci Rep. 2018 Feb 26;8(1):3660. doi: 10.1038/s41598-018-22081-7. Sci Rep. 2018. PMID: 29483571 Free PMC article.

9

Peptide Optimization at the Drug Discovery-Development Interface: Tailoring of Physicochemical Properties Toward Specific Formulation Requirements.

Evers A, Pfeiffer-Marek S, Bossart M, Heubel C, Stock U, Tiwari G, Gebauer B, Elshorst B, Pfenninger A, Lukasczyk U, Hessler G, Kamm W, Wagner M. Evers A, et al. Among authors: pfenninger a. J Pharm Sci. 2019 Apr;108(4):1404-1414. doi: 10.1016/j.xphs.2018.11.043. Epub 2018 Dec 4. J Pharm Sci. 2019. PMID: 30528197

10

A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution.

Maida A, Zota A, Sjøberg KA, Schumacher J, Sijmonsma TP, Pfenninger A, Christensen MM, Gantert T, Fuhrmeister J, Rothermel U, Schmoll D, Heikenwälder M, Iovanna JL, Stemmer K, Kiens B, Herzig S, Rose AJ. Maida A, et al. Among authors: pfenninger a. J Clin Invest. 2016 Sep 1;126(9):3263-78. doi: 10.1172/JCI85946. Epub 2016 Aug 22. J Clin Invest. 2016. PMID: 27548521 Free PMC article.

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