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Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases.
Link W, Oyarzabal J, Serelde BG, Albarran MI, Rabal O, Cebriá A, Alfonso P, Fominaya J, Renner O, Peregrina S, Soilán D, Ceballos PA, Hernández AI, Lorenzo M, Pevarello P, Granda TG, Kurz G, Carnero A, Bischoff JR. Link W, et al. Among authors: pevarello p. J Biol Chem. 2009 Oct 9;284(41):28392-28400. doi: 10.1074/jbc.M109.038984. Epub 2009 Aug 18. J Biol Chem. 2009. PMID: 19690175 Free PMC article.
CDK inhibitors in cancer therapy: what is next?
Malumbres M, Pevarello P, Barbacid M, Bischoff JR. Malumbres M, et al. Among authors: pevarello p. Trends Pharmacol Sci. 2008 Jan;29(1):16-21. doi: 10.1016/j.tips.2007.10.012. Epub 2007 Dec 4. Trends Pharmacol Sci. 2008. PMID: 18054800
Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition.
Blanco-Aparicio C, Collazo AM, Oyarzabal J, Leal JF, Albarán MI, Lima FR, Pequeño B, Ajenjo N, Becerra M, Alfonso P, Reymundo MI, Palacios I, Mateos G, Quiñones H, Corrionero A, Carnero A, Pevarello P, Lopez AR, Fominaya J, Pastor J, Bischoff JR. Blanco-Aparicio C, et al. Among authors: pevarello p. Cancer Lett. 2011 Jan 28;300(2):145-53. doi: 10.1016/j.canlet.2010.09.016. Epub 2010 Nov 3. Cancer Lett. 2011. PMID: 21051136
3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: a new class of CDK2 inhibitors.
Pevarello P, Fancelli D, Vulpetti A, Amici R, Villa M, Pittalà V, Vianello P, Cameron A, Ciomei M, Mercurio C, Bischoff JR, Roletto F, Varasi M, Brasca MG. Pevarello P, et al. Bioorg Med Chem Lett. 2006 Feb 15;16(4):1084-90. doi: 10.1016/j.bmcl.2005.10.071. Epub 2005 Nov 14. Bioorg Med Chem Lett. 2006. PMID: 16290148
Optimization of 6,6-dimethyl pyrrolo[3,4-c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing.
Brasca MG, Albanese C, Alzani R, Amici R, Avanzi N, Ballinari D, Bischoff J, Borghi D, Casale E, Croci V, Fiorentini F, Isacchi A, Mercurio C, Nesi M, Orsini P, Pastori W, Pesenti E, Pevarello P, Roussel P, Varasi M, Volpi D, Vulpetti A, Ciomei M. Brasca MG, et al. Among authors: pevarello p. Bioorg Med Chem. 2010 Mar 1;18(5):1844-53. doi: 10.1016/j.bmc.2010.01.042. Epub 2010 Jan 25. Bioorg Med Chem. 2010. PMID: 20153204
Benzodipyrazoles: a new class of potent CDK2 inhibitors.
D'Alessio R, Bargiotti A, Metz S, Brasca MG, Cameron A, Ermoli A, Marsiglio A, Polucci P, Roletto F, Tibolla M, Vazquez ML, Vulpetti A, Pevarello P. D'Alessio R, et al. Among authors: pevarello p. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1315-9. doi: 10.1016/j.bmcl.2005.01.023. Bioorg Med Chem Lett. 2005. PMID: 15713378
40 results