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TIA1 regulates the generation and response to toxic tau oligomers.
Jiang L, Ash PEA, Maziuk BF, Ballance HI, Boudeau S, Abdullatif AA, Orlando M, Petrucelli L, Ikezu T, Wolozin B. Jiang L, et al. Among authors: petrucelli l. Acta Neuropathol. 2019 Feb;137(2):259-277. doi: 10.1007/s00401-018-1937-5. Epub 2018 Nov 21. Acta Neuropathol. 2019. PMID: 30465259 Free PMC article.
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.
Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, Tsuboi Y, Dawson TM, Wolozin B, Hardy J, Hutton M. Petrucelli L, et al. Hum Mol Genet. 2004 Apr 1;13(7):703-14. doi: 10.1093/hmg/ddh083. Epub 2004 Feb 12. Hum Mol Genet. 2004. PMID: 14962978
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.
Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS Jr, Hutton M, Burrows F, Petrucelli L. Dickey CA, et al. Among authors: petrucelli l. J Clin Invest. 2007 Mar;117(3):648-58. doi: 10.1172/JCI29715. Epub 2007 Feb 15. J Clin Invest. 2007. PMID: 17304350 Free PMC article.
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.
Zhang YJ, Xu YF, Cook C, Gendron TF, Roettges P, Link CD, Lin WL, Tong J, Castanedes-Casey M, Ash P, Gass J, Rangachari V, Buratti E, Baralle F, Golde TE, Dickson DW, Petrucelli L. Zhang YJ, et al. Among authors: petrucelli l. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7607-12. doi: 10.1073/pnas.0900688106. Epub 2009 Apr 21. Proc Natl Acad Sci U S A. 2009. PMID: 19383787 Free PMC article.
Neurotoxic effects of TDP-43 overexpression in C. elegans.
Ash PE, Zhang YJ, Roberts CM, Saldi T, Hutter H, Buratti E, Petrucelli L, Link CD. Ash PE, et al. Among authors: petrucelli l. Hum Mol Genet. 2010 Aug 15;19(16):3206-18. doi: 10.1093/hmg/ddq230. Epub 2010 Jun 8. Hum Mol Genet. 2010. PMID: 20530643 Free PMC article.
322 results