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From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine.
Petrelli R, Meli M, Vita P, Torquati I, Ferro A, Vodnala M, D'Alessandro N, Tolomeo M, Del Bello F, Kusumanchi P, Franchetti P, Grifantini M, Jayaram HN, Hofer A, Cappellacci L. Petrelli R, et al. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5304-9. doi: 10.1016/j.bmcl.2014.09.046. Epub 2014 Sep 28. Bioorg Med Chem Lett. 2014. PMID: 25304896
5'-Chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A(1) receptor agonist, alleviates neuropathic pain in mice through functional glial and microglial changes without affecting motor or cardiovascular functions.
Luongo L, Petrelli R, Gatta L, Giordano C, Guida F, Vita P, Franchetti P, Grifantini M, de Novellis V, Cappellacci L, Maione S. Luongo L, et al. Among authors: petrelli r. Molecules. 2012 Nov 22;17(12):13712-26. doi: 10.3390/molecules171213712. Molecules. 2012. PMID: 23174891 Free PMC article.
Nicotinamide Adenine Dinucleotide Based Therapeutics, Update.
Pankiewicz KW, Petrelli R, Singh R, Felczak K. Pankiewicz KW, et al. Among authors: petrelli r. Curr Med Chem. 2015;22(34):3991-4028. doi: 10.2174/0929867322666150821100720. Curr Med Chem. 2015. PMID: 26295463 Review.
Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells.
Meli M, Tolomeo M, Grifantini M, Mai A, Cappellacci L, Petrelli R, Rotili D, Ferro A, Saiko P, Szekeres T, Dusonchet L. Meli M, et al. Among authors: petrelli r. Int J Oncol. 2011 May;38(5):1427-36. doi: 10.3892/ijo.2011.943. Epub 2011 Feb 11. Int J Oncol. 2011. PMID: 21318222
The A1 adenosine receptor as a new player in microglia physiology.
Luongo L, Guida F, Imperatore R, Napolitano F, Gatta L, Cristino L, Giordano C, Siniscalco D, Di Marzo V, Bellini G, Petrelli R, Cappellacci L, Usiello A, de Novellis V, Rossi F, Maione S. Luongo L, et al. Among authors: petrelli r. Glia. 2014 Jan;62(1):122-32. doi: 10.1002/glia.22592. Glia. 2014. PMID: 24272707
118 results