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Page 1
Towards the sustainable discovery and development of new antibiotics.
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo PB, Glaser P, Aigle B, Bode HB, Moreira R, Li Y, Luzhetskyy A, Medema MH, Pernodet JL, Stadler M, Tormo JR, Genilloud O, Truman AW, Weissman KJ, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch AKH, Loretz B, Lehr CM, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock LJV, Gilbert IH, Moser HE, Müller R. Miethke M, et al. Among authors: petkovic h. Nat Rev Chem. 2021;5(10):726-749. doi: 10.1038/s41570-021-00313-1. Epub 2021 Aug 19. Nat Rev Chem. 2021. PMID: 34426795 Free PMC article. Review.
Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin.
Hennessen F, Miethke M, Zaburannyi N, Loose M, Lukežič T, Bernecker S, Hüttel S, Jansen R, Schmiedel J, Fritzenwanker M, Imirzalioglu C, Vogel J, Westermann AJ, Hesterkamp T, Stadler M, Wagenlehner F, Petković H, Herrmann J, Müller R. Hennessen F, et al. Among authors: petkovic h. Antibiotics (Basel). 2020 Sep 18;9(9):619. doi: 10.3390/antibiotics9090619. Antibiotics (Basel). 2020. PMID: 32962088 Free PMC article.
Synthetic biology approaches to actinomycete strain improvement.
Breitling R, Avbelj M, Bilyk O, Carratore FD, Filisetti A, Hanko EKR, Iorio M, Redondo RP, Reyes F, Rudden M, Severi E, Slemc L, Schmidt K, Whittall DR, Donadio S, García AR, Genilloud O, Kosec G, De Lucrezia D, Petković H, Thomas G, Takano E. Breitling R, et al. Among authors: petkovic h. FEMS Microbiol Lett. 2021 Jun 11;368(10):fnab060. doi: 10.1093/femsle/fnab060. FEMS Microbiol Lett. 2021. PMID: 34057181 Free PMC article. Review.
Construction of a new class of tetracycline lead structures with potent antibacterial activity through biosynthetic engineering.
Lešnik U, Lukežič T, Podgoršek A, Horvat J, Polak T, Šala M, Jenko B, Harmrolfs K, Ocampo-Sosa A, Martínez-Martínez L, Herron PR, Fujs Š, Kosec G, Hunter IS, Müller R, Petković H. Lešnik U, et al. Among authors: petkovic h. Angew Chem Int Ed Engl. 2015 Mar 23;54(13):3937-40. doi: 10.1002/anie.201411028. Epub 2015 Feb 4. Angew Chem Int Ed Engl. 2015. PMID: 25650563 Free article.
Multiple copies of the oxytetracycline gene cluster in selected Streptomyces rimosus strains can provide significantly increased titers.
Pikl Š, Carrillo Rincón AF, Slemc L, Goranovič D, Avbelj M, Gjuračić K, Sucipto H, Stare K, Baebler Š, Šala M, Guo M, Luzhetskyy A, Petković H, Magdevska V. Pikl Š, et al. Among authors: petkovic h. Microb Cell Fact. 2021 Feb 17;20(1):47. doi: 10.1186/s12934-021-01522-5. Microb Cell Fact. 2021. PMID: 33596911 Free PMC article.
Reference-Grade Genome and Large Linear Plasmid of Streptomyces rimosus: Pushing the Limits of Nanopore Sequencing.
Slemc L, Jakše J, Filisetti A, Baranasic D, Rodríguez-García A, Del Carratore F, Marino SM, Zucko J, Starcevic A, Šala M, Pérez-Bonilla M, Sánchez-Hidalgo M, González I, Reyes F, Genilloud O, Springthorpe V, Goranovič D, Kosec G, Thomas GH, Lucrezia D, Petković H, Tome M. Slemc L, et al. Among authors: petkovic h. Microbiol Spectr. 2022 Apr 27;10(2):e0243421. doi: 10.1128/spectrum.02434-21. Epub 2022 Apr 4. Microbiol Spectr. 2022. PMID: 35377231 Free PMC article.
53 results