Peterson K - Search Results

1

Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease.

Zetterberg FR, MacKinnon A, Brimert T, Gravelle L, Johnsson RE, Kahl-Knutson B, Leffler H, Nilsson UJ, Pedersen A, Peterson K, Roper JA, Schambye H, Slack RJ, Tantawi S. Zetterberg FR, et al. Among authors: peterson k. J Med Chem. 2022 Oct 13;65(19):12626-12638. doi: 10.1021/acs.jmedchem.2c00660. Epub 2022 Sep 26. J Med Chem. 2022. PMID: 36154172 Free PMC article.

2

Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions.

Zetterberg FR, Peterson K, Johnsson RE, Brimert T, Håkansson M, Logan DT, Leffler H, Nilsson UJ. Zetterberg FR, et al. Among authors: peterson k. ChemMedChem. 2018 Jan 22;13(2):133-137. doi: 10.1002/cmdc.201700744. Epub 2018 Jan 15. ChemMedChem. 2018. PMID: 29194992

3

Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity.

Peterson K, Kumar R, Stenström O, Verma P, Verma PR, Håkansson M, Kahl-Knutsson B, Zetterberg F, Leffler H, Akke M, Logan DT, Nilsson UJ. Peterson K, et al. J Med Chem. 2018 Feb 8;61(3):1164-1175. doi: 10.1021/acs.jmedchem.7b01626. Epub 2018 Jan 11. J Med Chem. 2018. PMID: 29284090 Free article.

4

Galectin-3 is an amplifier of the interleukin-1β-mediated inflammatory response in corneal keratinocytes.

Uchino Y, Woodward AM, Mauris J, Peterson K, Verma P, Nilsson UJ, Rajaiya J, Argüeso P. Uchino Y, et al. Among authors: peterson k. Immunology. 2018 Jul;154(3):490-499. doi: 10.1111/imm.12899. Epub 2018 Feb 15. Immunology. 2018. PMID: 29359328 Free PMC article.

5

Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects.

Kumar R, Peterson K, Misini Ignjatović M, Leffler H, Ryde U, Nilsson UJ, Logan DT. Kumar R, et al. Among authors: peterson k. Org Biomol Chem. 2019 Jan 31;17(5):1081-1089. doi: 10.1039/c8ob02888e. Org Biomol Chem. 2019. PMID: 30632578

6

Structure and Energetics of Ligand-Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides: Insight into Solvation Effects and Multipolar Interactions.

Kumar R, Ignjatović MM, Peterson K, Olsson M, Leffler H, Ryde U, Nilsson UJ, Logan DT. Kumar R, et al. Among authors: peterson k. ChemMedChem. 2019 Aug 20;14(16):1528-1536. doi: 10.1002/cmdc.201900293. Epub 2019 Jul 11. ChemMedChem. 2019. PMID: 31246331 Free PMC article.

7

3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-sites for High-Affinity and High-Selectivity Inhibition of Galectin-3.

Dahlqvist A, Mandal S, Peterson K, Håkansson M, Logan DT, Zetterberg FR, Leffler H, Nilsson UJ. Dahlqvist A, et al. Among authors: peterson k. Molecules. 2019 Dec 12;24(24):4554. doi: 10.3390/molecules24244554. Molecules. 2019. PMID: 31842451 Free PMC article.

8

In Vivo Veritas: ¹⁸F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors.

Bratteby K, Torkelsson E, L'Estrade ET, Peterson K, Shalgunov V, Xiong M, Leffler H, Zetterberg FR, Olsson TG, Gillings N, Nilsson UJ, Herth MM, Erlandsson M. Bratteby K, et al. Among authors: peterson k. J Med Chem. 2020 Jan 23;63(2):747-755. doi: 10.1021/acs.jmedchem.9b01692. Epub 2020 Jan 3. J Med Chem. 2020. PMID: 31846326

9

Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C.

Wallerstein J, Ekberg V, Ignjatović MM, Kumar R, Caldararu O, Peterson K, Wernersson S, Brath U, Leffler H, Oksanen E, Logan DT, Nilsson UJ, Ryde U, Akke M. Wallerstein J, et al. Among authors: peterson k. JACS Au. 2021 Apr 1;1(4):484-500. doi: 10.1021/jacsau.0c00094. eCollection 2021 Apr 26. JACS Au. 2021. PMID: 34467311 Free PMC article.

10

Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands.

Peterson K, Collins PM, Huang X, Kahl-Knutsson B, Essén S, Zetterberg FR, Oredsson S, Leffler H, Blanchard H, Nilsson UJ. Peterson K, et al. RSC Adv. 2018 Jul 11;8(44):24913-24922. doi: 10.1039/c8ra04389b. eCollection 2018 Jul 9. RSC Adv. 2018. PMID: 35542159 Free PMC article.

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