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2015 2
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D-2-hydroxyglutarate supports a tolerogenic phenotype with lowered major histocompatibility class II expression in non-malignant dendritic cells and acute myeloid leukemia cells.
Hammon K, Renner K, Althammer M, Voll F, Babl N, Decking SM, Siska PJ, Matos C, Conejo ZEC, Mendes K, Einwag F, Siegmund H, Iberl S, Berger RS, Dettmer K, Schoenmehl R, Brochhausen C, Herr W, Oefner PJ, Rehli M, Thomas S, Kreutz M. Hammon K, et al. Among authors: siska pj. Haematologica. 2024 Jan 18. doi: 10.3324/haematol.2023.283597. Online ahead of print. Haematologica. 2024. PMID: 38235501 Free article.
Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating CD8+ T cells.
Riegel D, Romero-Fernández E, Simon M, Adenugba AR, Singer K, Mayr R, Weber F, Kleemann M, Imbusch CD, Kreutz M, Brors B, Ugele I, Werner JM, Siska PJ, Schmidl C. Riegel D, et al. Among authors: siska pj. Mol Cell. 2023 Feb 16;83(4):622-636.e10. doi: 10.1016/j.molcel.2022.12.029. Epub 2023 Jan 18. Mol Cell. 2023. PMID: 36657444 Free article.
Immunometabolic Markers in a Small Patient Cohort Undergoing Immunotherapy.
Hofbauer J, Hauck A, Matos C, Babl N, Decking SM, Rechenmacher M, Schulz C, Regotta S, Mickler M, Haferkamp S, Siska PJ, Herr W, Renner K, Kreutz M, Schnell A. Hofbauer J, et al. Among authors: siska pj. Biomolecules. 2022 May 18;12(5):716. doi: 10.3390/biom12050716. Biomolecules. 2022. PMID: 35625643 Free PMC article.
Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo.
Siska PJ, Jiao J, Matos C, Singer K, Berger RS, Dettmer K, Oefner PJ, Cully MD, Wang Z, QuinnIII WJ, Oliff KN, Wilkins BJ, Christensen LM, Wang L, Hancock WW, Baur JA, Levine MH, Ugele I, Mayr R, Renner K, Zhou L, Kreutz M, Beier UH. Siska PJ, et al. EBioMedicine. 2021 Dec;74:103734. doi: 10.1016/j.ebiom.2021.103734. Epub 2021 Dec 4. EBioMedicine. 2021. PMID: 34875457 Free PMC article.
Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasone.
Siska PJ, Decking SM, Babl N, Matos C, Bruss C, Singer K, Klitzke J, Schön M, Simeth J, Köstler J, Siegmund H, Ugele I, Paulus M, Dietl A, Kolodova K, Steines L, Freitag K, Peuker A, Schönhammer G, Raithel J, Graf B, Geismann F, Lubnow M, Mack M, Hau P, Bohr C, Burkhardt R, Gessner A, Salzberger B, Wagner R, Hanses F, Hitzenbichler F, Heudobler D, Lüke F, Pukrop T, Herr W, Wolff D, Spang R, Poeck H, Hoffmann P, Jantsch J, Brochhausen C, Lunz D, Rehli M, Kreutz M, Renner K. Siska PJ, et al. J Clin Invest. 2021 Nov 15;131(22):e148225. doi: 10.1172/JCI148225. J Clin Invest. 2021. PMID: 34779418 Free PMC article.
Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.
Healey DCC, Cephus JY, Barone SM, Chowdhury NU, Dahunsi DO, Madden MZ, Ye X, Yu X, Olszewski K, Young K, Gerriets VA, Siska PJ, Dworski R, Hemler J, Locasale JW, Poyurovsky MV, Peebles RS Jr, Irish JM, Newcomb DC, Rathmell JC. Healey DCC, et al. Among authors: siska pj. J Immunol. 2021 Mar 15;206(6):1127-1139. doi: 10.4049/jimmunol.2001029. Epub 2021 Feb 8. J Immunol. 2021. PMID: 33558372 Free PMC article.
37 results