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Harmicines - harmine and cinnamic acid hybrids as novel antiplasmodial hits.
Perković I, Raić-Malić S, Fontinha D, Prudêncio M, Pessanha de Carvalho L, Held J, Tandarić T, Vianello R, Zorc B, Rajić Z. Perković I, et al. Among authors: pessanha de carvalho l. Eur J Med Chem. 2020 Feb 1;187:111927. doi: 10.1016/j.ejmech.2019.111927. Epub 2019 Nov 29. Eur J Med Chem. 2020. PMID: 31812035
Further investigation of harmicines as novel antiplasmodial agents: Synthesis, structure-activity relationship and insight into the mechanism of action.
Marinović M, Poje G, Perković I, Fontinha D, Prudêncio M, Held J, Pessanha de Carvalho L, Tandarić T, Vianello R, Rajić Z. Marinović M, et al. Among authors: pessanha de carvalho l. Eur J Med Chem. 2021 Nov 15;224:113687. doi: 10.1016/j.ejmech.2021.113687. Epub 2021 Jul 5. Eur J Med Chem. 2021. PMID: 34274829
Novel Harmicines with Improved Potency against Plasmodium.
Marinović M, Perković I, Fontinha D, Prudêncio M, Held J, Pessanha de Carvalho L, Tandarić T, Vianello R, Zorc B, Rajić Z. Marinović M, et al. Among authors: pessanha de carvalho l. Molecules. 2020 Sep 23;25(19):4376. doi: 10.3390/molecules25194376. Molecules. 2020. PMID: 32977642 Free PMC article.
3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum.
Knaab TC, Held J, Burckhardt BB, Rubiano K, Okombo J, Yeo T, Mok S, Uhlemann AC, Lungerich B, Fischli C, Pessanha de Carvalho L, Mordmüller B, Wittlin S, Fidock DA, Kurz T. Knaab TC, et al. Among authors: pessanha de carvalho l. J Med Chem. 2021 Mar 25;64(6):3035-3047. doi: 10.1021/acs.jmedchem.0c01744. Epub 2021 Mar 5. J Med Chem. 2021. PMID: 33666415 Free PMC article.
Discovery of harmiprims, harmine-primaquine hybrids, as potent and selective anticancer and antimalarial compounds.
Pavić K, Poje G, Pessanha de Carvalho L, Tandarić T, Marinović M, Fontinha D, Held J, Prudêncio M, Piantanida I, Vianello R, Krošl Knežević I, Perković I, Rajić Z. Pavić K, et al. Among authors: pessanha de carvalho l. Bioorg Med Chem. 2024 May 1;105:117734. doi: 10.1016/j.bmc.2024.117734. Epub 2024 Apr 23. Bioorg Med Chem. 2024. PMID: 38677112
Reverse N-Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR).
Abdullaziz MA, Takada S, Illarionov B, Pessanha de Carvalho L, Sakamoto Y, Höfmann S, Knak T, Kiffe-Delf AL, Mazzone F, Pfeffer K, Kalscheuer R, Bacher A, Held J, Fischer M, Tanaka N, Kurz T. Abdullaziz MA, et al. Among authors: pessanha de carvalho l. ACS Infect Dis. 2024 May 10;10(5):1739-1752. doi: 10.1021/acsinfecdis.4c00100. Epub 2024 Apr 22. ACS Infect Dis. 2024. PMID: 38647213
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