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FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.
Bravard A, Lefai E, Meugnier E, Pesenti S, Disse E, Vouillarmet J, Peretti N, Rabasa-Lhoret R, Laville M, Vidal H, Rieusset J. Bravard A, et al. Among authors: pesenti s. Diabetes. 2011 Jan;60(1):258-68. doi: 10.2337/db10-0281. Epub 2010 Oct 13. Diabetes. 2011. PMID: 20943749 Free PMC article.
Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice.
Aswad H, Forterre A, Wiklander OP, Vial G, Danty-Berger E, Jalabert A, Lamazière A, Meugnier E, Pesenti S, Ott C, Chikh K, El-Andaloussi S, Vidal H, Lefai E, Rieusset J, Rome S. Aswad H, et al. Among authors: pesenti s. Diabetologia. 2014 Oct;57(10):2155-64. doi: 10.1007/s00125-014-3337-2. Epub 2014 Jul 30. Diabetologia. 2014. PMID: 25073444 Free PMC article.
Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients.
Hokayem M, Blond E, Vidal H, Lambert K, Meugnier E, Feillet-Coudray C, Coudray C, Pesenti S, Luyton C, Lambert-Porcheron S, Sauvinet V, Fedou C, Brun JF, Rieusset J, Bisbal C, Sultan A, Mercier J, Goudable J, Dupuy AM, Cristol JP, Laville M, Avignon A. Hokayem M, et al. Among authors: pesenti s. Diabetes Care. 2013 Jun;36(6):1454-61. doi: 10.2337/dc12-1652. Epub 2012 Dec 28. Diabetes Care. 2013. PMID: 23275372 Free PMC article. Clinical Trial.
Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice.
Jalabert A, Vial G, Guay C, Wiklander OP, Nordin JZ, Aswad H, Forterre A, Meugnier E, Pesenti S, Regazzi R, Danty-Berger E, Ducreux S, Vidal H, El-Andaloussi S, Rieusset J, Rome S. Jalabert A, et al. Among authors: pesenti s. Diabetologia. 2016 May;59(5):1049-58. doi: 10.1007/s00125-016-3882-y. Epub 2016 Feb 6. Diabetologia. 2016. PMID: 26852333
154 results