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An expeditive and green chemo-enzymatic route to diester sinapoyl-l-malate analogues: sustainable bioinspired and biosourced UV filters and molecular heaters.
Rioux B, Mouterde LMM, Alarcan J, Abiola TT, Vink MJA, Woolley JM, Peru AAM, Mention MM, Brunissen F, Berden G, Oomens J, Braeuning A, Stavros VG, Allais F. Rioux B, et al. Among authors: peru aam. Chem Sci. 2023 Nov 21;14(47):13962-13978. doi: 10.1039/d3sc04836e. eCollection 2023 Dec 6. Chem Sci. 2023. PMID: 38075651 Free PMC article.
Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): a potent and selective inhibitor of PI3Kβ and PI3Kδ for the treatment of PTEN-deficient cancers.
Barlaam B, Cosulich S, Degorce S, Fitzek M, Green S, Hancox U, Lambert-van der Brempt C, Lohmann JJ, Maudet M, Morgentin R, Pasquet MJ, Péru A, Plé P, Saleh T, Vautier M, Walker M, Ward L, Warin N. Barlaam B, et al. J Med Chem. 2015 Jan 22;58(2):943-62. doi: 10.1021/jm501629p. Epub 2015 Jan 7. J Med Chem. 2015. PMID: 25514658
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