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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón-Sandoval J, Ribe E, Winchester L, Webber C, Nevado A, Jacobs T, Austin N, Theunis C, Grauwen K, Daniela Ruiz E, Mudher A, Vicente-Rodriguez M, Parker CA, Simmons C, Cash D, Richardson J; NIMA Consortium; Jones DNC, Lovestone S, Gómez-Nicola D, Perry VH. Mancuso R, et al. Among authors: perry vh. Brain. 2019 Oct 1;142(10):3243-3264. doi: 10.1093/brain/awz241. Brain. 2019. PMID: 31504240 Free PMC article.
Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration.
Gomez-Nicola D, Suzzi S, Vargas-Caballero M, Fransen NL, Al-Malki H, Cebrian-Silla A, Garcia-Verdugo JM, Riecken K, Fehse B, Perry VH. Gomez-Nicola D, et al. Among authors: perry vh. Brain. 2014 Aug;137(Pt 8):2312-28. doi: 10.1093/brain/awu155. Epub 2014 Jun 18. Brain. 2014. PMID: 24941947 Free PMC article.
Microglia regulate hippocampal neurogenesis during chronic neurodegeneration.
De Lucia C, Rinchon A, Olmos-Alonso A, Riecken K, Fehse B, Boche D, Perry VH, Gomez-Nicola D. De Lucia C, et al. Among authors: perry vh. Brain Behav Immun. 2016 Jul;55:179-190. doi: 10.1016/j.bbi.2015.11.001. Epub 2015 Nov 2. Brain Behav Immun. 2016. PMID: 26541819 Free PMC article.
Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration.
Obst J, Simon E, Martin-Estebane M, Pipi E, Barkwill LM, Gonzalez-Rivera I, Buchanan F, Prescott AR, Faust D, Fox S, Brownlees J, Taylor D, Perry VH, Nuthall H, Atkinson PJ, Karran E, Routledge C, Gomez-Nicola D. Obst J, et al. Among authors: perry vh. Front Immunol. 2020 Oct 8;11:579000. doi: 10.3389/fimmu.2020.579000. eCollection 2020. Front Immunol. 2020. PMID: 33162994 Free PMC article.
The use of human neurons for novel drug discovery in dementia research.
Vargas-Caballero M, Willaime-Morawek S, Gomez-Nicola D, Perry VH, Bulters D, Mudher A. Vargas-Caballero M, et al. Among authors: perry vh. Expert Opin Drug Discov. 2016;11(4):355-67. doi: 10.1517/17460441.2016.1154528. Epub 2016 Mar 1. Expert Opin Drug Discov. 2016. PMID: 26878555 Review.
344 results