Perrino F - Search Results

1

Genotype-Phenotype Correlation and Functional Insights for Two Monoallelic TREX1 Missense Variants Affecting the Catalytic Core.

Amico G, Hemphill WO, Severino M, Moratti C, Pascarella R, Bertamino M, Napoli F, Volpi S, Rosamilia F, Signa S, Perrino F, Zedde M, Ceccherini I, On Behalf Of The Gaslini Stroke Study Group. Amico G, et al. Among authors: perrino f. Genes (Basel). 2022 Jun 30;13(7):1179. doi: 10.3390/genes13071179. Genes (Basel). 2022. PMID: 35885962 Free PMC article.

2

Measuring TREX1 and TREX2 exonuclease activities.

Hemphill WO, Perrino FW. Hemphill WO, et al. Methods Enzymol. 2019;625:109-133. doi: 10.1016/bs.mie.2019.05.004. Epub 2019 Jun 8. Methods Enzymol. 2019. PMID: 31455522 Free PMC article.

3

TREX1 - Apex predator of cytosolic DNA metabolism.

Simpson SR, Hemphill WO, Hudson T, Perrino FW. Simpson SR, et al. DNA Repair (Amst). 2020 Oct;94:102894. doi: 10.1016/j.dnarep.2020.102894. Epub 2020 Jun 12. DNA Repair (Amst). 2020. PMID: 32615442 Free PMC article.

4

TREX1 as a Novel Immunotherapeutic Target.

Hemphill WO, Simpson SR, Liu M, Salsbury FR Jr, Hollis T, Grayson JM, Perrino FW. Hemphill WO, et al. Front Immunol. 2021 Apr 1;12:660184. doi: 10.3389/fimmu.2021.660184. eCollection 2021. Front Immunol. 2021. PMID: 33868310 Free PMC article.

5

T Cells Produce IFN-α in the TREX1 D18N Model of Lupus-like Autoimmunity.

Simpson SR, Rego SL, Harvey SE, Liu M, Hemphill WO, Venkatadri R, Sharma R, Grayson JM, Perrino FW. Simpson SR, et al. J Immunol. 2020 Jan 15;204(2):348-359. doi: 10.4049/jimmunol.1900220. Epub 2019 Dec 11. J Immunol. 2020. PMID: 31826941 Free PMC article.

6

TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis.

Rego SL, Harvey S, Simpson SR, Hemphill WO, McIver ZA, Grayson JM, Perrino FW. Rego SL, et al. Autoimmunity. 2018 Nov;51(7):333-344. doi: 10.1080/08916934.2018.1522305. Epub 2018 Nov 13. Autoimmunity. 2018. PMID: 30422000 Free PMC article.

7

The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.

Lehtinen DA, Harvey S, Mulcahy MJ, Hollis T, Perrino FW. Lehtinen DA, et al. J Biol Chem. 2008 Nov 14;283(46):31649-56. doi: 10.1074/jbc.M806155200. Epub 2008 Sep 18. J Biol Chem. 2008. PMID: 18805785 Free PMC article.

8

Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.

Fye JM, Orebaugh CD, Coffin SR, Hollis T, Perrino FW. Fye JM, et al. J Biol Chem. 2011 Sep 16;286(37):32373-82. doi: 10.1074/jbc.M111.276287. Epub 2011 Aug 1. J Biol Chem. 2011. PMID: 21808053 Free PMC article.

9

Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease.

Bailey SL, Harvey S, Perrino FW, Hollis T. Bailey SL, et al. DNA Repair (Amst). 2012 Jan 2;11(1):65-73. doi: 10.1016/j.dnarep.2011.10.007. Epub 2011 Nov 8. DNA Repair (Amst). 2012. PMID: 22071149 Free PMC article.

10

The TREX1 C-terminal region controls cellular localization through ubiquitination.

Orebaugh CD, Fye JM, Harvey S, Hollis T, Wilkinson JC, Perrino FW. Orebaugh CD, et al. J Biol Chem. 2013 Oct 4;288(40):28881-92. doi: 10.1074/jbc.M113.503391. Epub 2013 Aug 26. J Biol Chem. 2013. PMID: 23979357 Free PMC article.

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