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A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog.
Christensen D, Henriksen-Lacey M, Kamath AT, Lindenstrøm T, Korsholm KS, Christensen JP, Rochat AF, Lambert PH, Andersen P, Siegrist CA, Perrie Y, Agger EM. Christensen D, et al. Among authors: perrie y. J Control Release. 2012 Jun 28;160(3):468-76. doi: 10.1016/j.jconrel.2012.03.016. Epub 2012 Mar 27. J Control Release. 2012. PMID: 22709414
The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8(+) T-cell responses: The immunological consequences of the biodistribution profile.
Schmidt ST, Khadke S, Korsholm KS, Perrie Y, Rades T, Andersen P, Foged C, Christensen D. Schmidt ST, et al. Among authors: perrie y. J Control Release. 2016 Oct 10;239:107-17. doi: 10.1016/j.jconrel.2016.08.034. Epub 2016 Aug 26. J Control Release. 2016. PMID: 27574990 Free PMC article.
Lipid conjugation of TLR7 agonist Resiquimod ensures co-delivery with the liposomal Cationic Adjuvant Formulation 01 (CAF01) but does not enhance immunopotentiation compared to non-conjugated Resiquimod+CAF01.
Wilkinson A, Lattmann E, Roces CB, Pedersen GK, Christensen D, Perrie Y. Wilkinson A, et al. Among authors: perrie y. J Control Release. 2018 Dec 10;291:1-10. doi: 10.1016/j.jconrel.2018.10.002. Epub 2018 Oct 3. J Control Release. 2018. PMID: 30291987 Free article.
157 results