Perreault M - Search Results

1

Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model.

Perreault M, Maltais R, Roy J, Picard S, Popa I, Bertrand N, Poirier D. Perreault M, et al. Invest New Drugs. 2019 Jun;37(3):431-440. doi: 10.1007/s10637-018-0643-4. Epub 2018 Jul 30. Invest New Drugs. 2019. PMID: 30062573

2

Explorative study on the anticancer activity, selectivity and metabolic stability of related analogs of aminosteroid RM-133.

Perreault M, Maltais R, Dutour R, Poirier D. Perreault M, et al. Steroids. 2016 Nov;115:105-113. doi: 10.1016/j.steroids.2016.08.015. Epub 2016 Aug 21. Steroids. 2016. PMID: 27553727

3

Design of a Mestranol 2-N-Piperazino-Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF-7 Breast Cancer Models.

Perreault M, Maltais R, Roy J, Dutour R, Poirier D. Perreault M, et al. ChemMedChem. 2017 Jan 20;12(2):177-182. doi: 10.1002/cmdc.201600482. Epub 2017 Jan 6. ChemMedChem. 2017. PMID: 28060448

4

Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133.

Perreault M, Maltais R, Kenmogne LC, Létourneau D, LeHoux JG, Gobeil S, Poirier D. Perreault M, et al. Pharmacol Res. 2018 Feb;128:52-60. doi: 10.1016/j.phrs.2017.12.024. Epub 2017 Dec 26. Pharmacol Res. 2018. PMID: 29287690

5

Parallel Solid-Phase Synthesis using a New Diethylsilylacetylenic Linker and Leading to Mestranol Derivatives with Potent Antiproliferative Activities on Multiple Cancer Cell Lines.

Dutour R, Maltais R, Perreault M, Roy J, Poirier D. Dutour R, et al. Among authors: perreault m. Anticancer Agents Med Chem. 2018;18(10):1469-1481. doi: 10.2174/1871520618666180307130158. Anticancer Agents Med Chem. 2018. PMID: 29521249

6

Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility.

Maltais R, Perreault M, Roy J, Poirier D. Maltais R, et al. Among authors: perreault m. Eur J Med Chem. 2020 Feb 15;188:111990. doi: 10.1016/j.ejmech.2019.111990. Epub 2019 Dec 23. Eur J Med Chem. 2020. PMID: 31893547

7

Induction of Endoplasmic Reticulum Stress-Mediated Apoptosis by Aminosteroid RM-581 Efficiently Blocks the Growth of PC-3 Cancer Cells and Tumors Resistant or Not to Docetaxel.

Maltais R, Roy J, Perreault M, Sato S, Lévesque JC, Poirier D. Maltais R, et al. Among authors: perreault m. Int J Mol Sci. 2021 Oct 17;22(20):11181. doi: 10.3390/ijms222011181. Int J Mol Sci. 2021. PMID: 34681843 Free PMC article.

8

Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1.

Trottier A, Maltais R, Ayan D, Barbeau X, Roy J, Perreault M, Poulin R, Lagüe P, Poirier D. Trottier A, et al. Among authors: perreault m. Biochem Pharmacol. 2017 Nov 15;144:149-161. doi: 10.1016/j.bcp.2017.08.004. Epub 2017 Aug 9. Biochem Pharmacol. 2017. PMID: 28800957

9

A- and D-Ring Structural Modifications of an Androsterone Derivative Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3: Chemical Synthesis and Structure-Activity Relationships.

Cortés-Benítez F, Roy J, Perreault M, Maltais R, Poirier D. Cortés-Benítez F, et al. Among authors: perreault m. J Med Chem. 2019 Aug 8;62(15):7070-7088. doi: 10.1021/acs.jmedchem.9b00624. Epub 2019 Jul 19. J Med Chem. 2019. PMID: 31268309

10

16-Picolyl-androsterone derivative exhibits potent 17β-HSD3 inhibitory activity, improved metabolic stability and cytotoxic effect on various cancer cells: Synthesis, homology modeling and docking studies.

Cortés-Benítez F, Roy J, Perreault M, Maltais R, Poirier D. Cortés-Benítez F, et al. Among authors: perreault m. J Steroid Biochem Mol Biol. 2021 Jun;210:105846. doi: 10.1016/j.jsbmb.2021.105846. Epub 2021 Feb 18. J Steroid Biochem Mol Biol. 2021. PMID: 33609690

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