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Molecular targets and mechanisms for ethanol action in glycine receptors.
Pharmacol Ther. 2010 Jul;127(1):53-65. doi: 10.1016/j.pharmthera.2010.03.003. Epub 2010 Apr 23.
Pharmacol Ther. 2010.
PMID: 20399807
Free PMC article.
Review.
Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors.
Asatryan L, Popova M, Perkins D, Trudell JR, Alkana RL, Davies DL.
Asatryan L, et al.
J Pharmacol Exp Ther. 2010 Sep 1;334(3):720-8. doi: 10.1124/jpet.110.167908. Epub 2010 Jun 11.
J Pharmacol Exp Ther. 2010.
PMID: 20543096
Free PMC article.
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Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors.
Perkins DI, Trudell JR, Crawford DK, Alkana RL, Davies DL.
Perkins DI, et al.
J Neurochem. 2008 Aug;106(3):1337-49. doi: 10.1111/j.1471-4159.2008.05476.x. Epub 2008 May 12.
J Neurochem. 2008.
PMID: 18485105
Free PMC article.
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Roles for loop 2 residues of alpha1 glycine receptors in agonist activation.
Crawford DK, Perkins DI, Trudell JR, Bertaccini EJ, Davies DL, Alkana RL.
Crawford DK, et al. Among authors: perkins di.
J Biol Chem. 2008 Oct 10;283(41):27698-27706. doi: 10.1074/jbc.M802384200. Epub 2008 Jul 25.
J Biol Chem. 2008.
PMID: 18658152
Free PMC article.
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Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity.
Perkins DI, Trudell JR, Crawford DK, Asatryan L, Alkana RL, Davies DL.
Perkins DI, et al.
J Biol Chem. 2009 Oct 2;284(40):27304-14. doi: 10.1074/jbc.M109.023598. Epub 2009 Aug 5.
J Biol Chem. 2009.
PMID: 19656948
Free PMC article.
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Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors.
Perkins DI, Trudell JR, Asatryan L, Davies DL, Alkana RL.
Perkins DI, et al.
J Pharmacol Exp Ther. 2012 May;341(2):543-51. doi: 10.1124/jpet.111.190942. Epub 2012 Feb 22.
J Pharmacol Exp Ther. 2012.
PMID: 22357974
Free PMC article.
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Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.
Naito A, Muchhala KH, Asatryan L, Trudell JR, Homanics GE, Perkins DI, Davies DL, Alkana RL.
Naito A, et al. Among authors: perkins di.
Mol Pharmacol. 2014 Dec;86(6):635-46. doi: 10.1124/mol.114.093773. Epub 2014 Sep 22.
Mol Pharmacol. 2014.
PMID: 25245406
Free PMC article.
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Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes.
Li K, Xu L, Kulkarni AA, Perkins DI, Haworth IS, Davies DL.
Li K, et al. Among authors: perkins di.
Alcohol Clin Exp Res. 2008 May;32(5):777-84. doi: 10.1111/j.1530-0277.2008.00636.x. Epub 2008 Mar 11.
Alcohol Clin Exp Res. 2008.
PMID: 18336632
Free PMC article.
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