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Transcending the challenge of evolving resistance mechanisms in Pseudomonas aeruginosa through β-lactam-enhancer-mechanism-based cefepime/zidebactam.
Hujer AM, Marshall SH, Mack AR, Hujer KM, Bakthavatchalam YD, Umarkar K, Palwe SR, Takalkar S, Joshi PR, Shrivastava R, Periasamy H, Bhagwat SS, Patel MV, Veeraraghavan B, Bonomo RA. Hujer AM, et al. Among authors: periasamy h. mBio. 2023 Oct 27;14(6):e0111823. doi: 10.1128/mbio.01118-23. Online ahead of print. mBio. 2023. PMID: 37889005 Free PMC article.
In Vitro and In Vivo Activities of β-Lactams in Combination with the Novel β-Lactam Enhancers Zidebactam and WCK 5153 against Multidrug-Resistant Metallo-β-Lactamase-Producing Klebsiella pneumoniae.
Moya B, Barcelo IM, Cabot G, Torrens G, Palwe S, Joshi P, Umarkar K, Takalkar S, Periasamy H, Bhagwat S, Patel M, Bou G, Oliver A. Moya B, et al. Among authors: periasamy h. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e00128-19. doi: 10.1128/AAC.00128-19. Print 2019 May. Antimicrob Agents Chemother. 2019. PMID: 30782985 Free PMC article.
In vitro activity of cefepime/zidebactam (WCK 5222) against recent Gram-negative isolates collected from high resistance settings of Greek hospitals.
Bhagwat SS, Legakis NJ, Skalidis T, Loannidis A, Goumenopoulos C, Joshi PR, Shrivastava R, Palwe SR, Periasamy H, Patel MV, Chatzipanagiotou S; Hellenic Cefepime/Zidebactam Study Group. Bhagwat SS, et al. Among authors: periasamy h. Diagn Microbiol Infect Dis. 2021 Jul;100(3):115327. doi: 10.1016/j.diagmicrobio.2021.115327. Epub 2021 Jan 30. Diagn Microbiol Infect Dis. 2021. PMID: 33744624
In vitro evolution of cefepime/zidebactam (WCK 5222) resistance in Pseudomonas aeruginosa: dynamics, mechanisms, fitness trade-off and impact on in vivo efficacy.
Barceló I, Cabot G, Palwe S, Joshi P, Takalkar S, Periasamy H, Cortés-Lara S, Zamorano L, Sánchez-Diener I, Moya B, Bhagwat S, Patel M, Oliver A. Barceló I, et al. Among authors: periasamy h. J Antimicrob Chemother. 2021 Sep 15;76(10):2546-2557. doi: 10.1093/jac/dkab213. J Antimicrob Chemother. 2021. PMID: 34219168
Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence.
Bhagwat SS, Nandanwar M, Kansagara A, Patel A, Takalkar S, Chavan R, Periasamy H, Yeole R, Deshpande PK, Bhavsar S, Bhatia A, Ahdal J, Jain R, Patel M. Bhagwat SS, et al. Among authors: periasamy h. Drug Des Devel Ther. 2019 Dec 24;13:4351-4365. doi: 10.2147/DDDT.S229882. eCollection 2019. Drug Des Devel Ther. 2019. PMID: 31920285 Free PMC article. Review.
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