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PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development.
Lau HH, Krentz NAJ, Abaitua F, Perez-Alcantara M, Chan JW, Ajeian J, Ghosh S, Lee Y, Yang J, Thaman S, Champon B, Sun H, Jha A, Hoon S, Tan NS, Gardner DS, Kao SL, Tai ES, Gloyn AL, Teo AKK. Lau HH, et al. Among authors: perez alcantara m. Nat Commun. 2023 Sep 30;14(1):6119. doi: 10.1038/s41467-023-41860-z. Nat Commun. 2023. PMID: 37777536 Free PMC article.
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression.
Mattis KK, Krentz NAJ, Metzendorf C, Abaitua F, Spigelman AF, Sun H, Ikle JM, Thaman S, Rottner AK, Bautista A, Mazzaferro E, Perez-Alcantara M, Manning Fox JE, Torres JM, Wesolowska-Andersen A, Yu GZ, Mahajan A, Larsson A, MacDonald PE, Davies B, den Hoed M, Gloyn AL. Mattis KK, et al. Among authors: perez alcantara m. Diabetologia. 2023 Apr;66(4):674-694. doi: 10.1007/s00125-022-05856-6. Epub 2023 Jan 12. Diabetologia. 2023. PMID: 36633628 Free PMC article.