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Oxidative Phosphorylation Fueled by Fatty Acid Oxidation Sensitizes Leukemic Stem Cells to Cold.
Griessinger E, Pereira-Martins D, Nebout M, Bosc C, Saland E, Boet E, Sahal A, Chiche J, Debayle D, Fleuriot L, Pruis M, De Mas V, Vergez F, Récher C, Huls G, Sarry JE, Schuringa JJ, Peyron JF. Griessinger E, et al. Among authors: pereira martins d. Cancer Res. 2023 Aug 1;83(15):2461-2470. doi: 10.1158/0008-5472.CAN-23-1006. Cancer Res. 2023. PMID: 37272750 Free PMC article.
The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy.
Lima K, Pereira-Martins DA, de Miranda LBL, Coelho-Silva JL, Leandro GDS, Weinhäuser I, Cavaglieri RC, Leal AM, da Silva WF, Lange APAL, Velloso EDRP, Griessinger E, Hilberink JR, Ammatuna E, Huls G, Schuringa JJ, Rego EM, Machado-Neto JA. Lima K, et al. Blood Cancer J. 2022 Nov 9;12(11):151. doi: 10.1038/s41408-022-00747-w. Blood Cancer J. 2022. PMID: 36347832 Free PMC article.
The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia.
Erdem A, Marin S, Pereira-Martins DA, Cortés R, Cunningham A, Pruis MG, de Boer B, van den Heuvel FAJ, Geugien M, Wierenga ATJ, Brouwers-Vos AZ, Rego EM, Huls G, Cascante M, Schuringa JJ. Erdem A, et al. Nat Commun. 2022 Mar 1;13(1):1105. doi: 10.1038/s41467-022-28737-3. Nat Commun. 2022. PMID: 35232995 Free PMC article.
Dietary methionine starvation impairs acute myeloid leukemia progression.
Cunningham A, Erdem A, Alshamleh I, Geugien M, Pruis M, Pereira-Martins DA, van den Heuvel FAJ, Wierenga ATJ, Ten Berge H, Dennebos R, van den Boom V, Hogeling SM, Weinhäuser I, Knops R, de Blaauw P, Heiner-Fokkema MR, Woolthuis C, Günther UL, Rego EM, Martens JHA, Jansen JH, Schwalbe H, Huls G, Schuringa JJ. Cunningham A, et al. Blood. 2022 Nov 10;140(19):2037-2052. doi: 10.1182/blood.2022017575. Blood. 2022. PMID: 35984907 Free article.
M2 macrophages drive leukemic transformation by imposing resistance to phagocytosis and improving mitochondrial metabolism.
Weinhäuser I, Pereira-Martins DA, Almeida LY, Hilberink JR, Silveira DRA, Quek L, Ortiz C, Araujo CL, Bianco TM, Lucena-Araujo A, Mota JM, Hogeling SM, Sternadt D, Visser N, Diepstra A, Ammatuna E, Huls G, Rego EM, Schuringa JJ. Weinhäuser I, et al. Sci Adv. 2023 Apr 14;9(15):eadf8522. doi: 10.1126/sciadv.adf8522. Epub 2023 Apr 14. Sci Adv. 2023. PMID: 37058562 Free article.
Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia.
Pereira-Martins DA, Coelho-Silva JL, Weinhäuser I, Franca-Neto PL, Silveira DR, Ortiz C, Moreira-Aguiar A, Lima MM, Koury LC, de Melo RA, Glória AB, Fagundes EM, Lino BK, Pagnano K, Bittencourt R, Nunes E, Traina F, Figueiredo-Pontes L, Keating A, Tallman MS, Ribeiro RC, Dilon R, Ganser A, Sanz MA, Berliner N, Valk P, Löwenberg B, Ottone T, Noguera NI, Voso MT, Paoloni F, Fazi P, Ammatuna E, Huls G, Schuringa JJ, Rego EM, Lucena-Araujo AR. Pereira-Martins DA, et al. Br J Haematol. 2023 Jan;200(2):170-174. doi: 10.1111/bjh.18510. Epub 2022 Oct 20. Br J Haematol. 2023. PMID: 36263593
45 results