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Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant Cells.
Sacramento CQ, Fintelman-Rodrigues N, Dias SSG, Temerozo JR, Da Silva APD, da Silva CS, Blanco C, Ferreira AC, Mattos M, Soares VC, Pereira-Dutra F, Miranda MD, Barreto-Vieira DF, da Silva MAN, Santos SS, Torres M, Chaves OA, Rajoli RKR, Paccanaro A, Owen A, Bou-Habib DC, Bozza PT, Souza TML. Sacramento CQ, et al. Viruses. 2022 Feb 11;14(2):374. doi: 10.3390/v14020374. Viruses. 2022. PMID: 35215969 Free PMC article.
Apixaban, an orally available anticoagulant, inhibits SARS-CoV-2 replication and its major protease in a non-competitive way.
Chaves OA, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, Pereira-Dutra F, Mizurini DM, Monteiro RQ, Vazquez L, Bozza PT, Castro-Faria-Neto HC, Souza TML. Chaves OA, et al. Among authors: pereira dutra f. J Mol Cell Biol. 2022 Sep 21;14(6):mjac039. doi: 10.1093/jmcb/mjac039. J Mol Cell Biol. 2022. PMID: 35759391 Free PMC article. No abstract available.
Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid Rafts.
Teixeira L, Temerozo JR, Pereira-Dutra FS, Ferreira AC, Mattos M, Gonçalves BS, Sacramento CQ, Palhinha L, Cunha-Fernandes T, Dias SSG, Soares VC, Barreto EA, Cesar-Silva D, Fintelman-Rodrigues N, Pão CRR, de Freitas CS, Reis PA, Hottz ED, Bozza FA, Bou-Habib DC, Saraiva EM, de Almeida CJG, Viola JPB, Souza TML, Bozza PT. Teixeira L, et al. Among authors: pereira dutra fs. Front Immunol. 2022 Feb 18;13:820131. doi: 10.3389/fimmu.2022.820131. eCollection 2022. Front Immunol. 2022. PMID: 35251001 Free PMC article.
Clotrimazole presents anticancer properties against a mouse melanoma model acting as a PI3K inhibitor and inducing repolarization of tumor-associated macrophages.
Ochioni AC, Imbroisi Filho R, Esteves AM, Leandro JGB, Demaria TM, do Nascimento Júnior JX, Pereira-Dutra FS, Bozza PT, Sola-Penna M, Zancan P. Ochioni AC, et al. Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1;1867(12):166263. doi: 10.1016/j.bbadis.2021.166263. Epub 2021 Sep 2. Biochim Biophys Acta Mol Basis Dis. 2021. PMID: 34481868 Free article.
The Endolysosomal System: The Acid Test for SARS-CoV-2.
Cesar-Silva D, Pereira-Dutra FS, Moraes Giannini AL, Jacques G de Almeida C. Cesar-Silva D, et al. Among authors: pereira dutra fs. Int J Mol Sci. 2022 Apr 20;23(9):4576. doi: 10.3390/ijms23094576. Int J Mol Sci. 2022. PMID: 35562967 Free PMC article. Review.
Lipid droplet accumulation occurs early following Salmonella infection and contributes to intracellular bacterial survival and replication.
Kiarely Souza E, Pereira-Dutra FS, Rajão MA, Ferraro-Moreira F, Goltara-Gomes TC, Cunha-Fernandes T, Santos JDC, Prestes EB, Andrade WA, Zamboni DS, Bozza MT, Bozza PT. Kiarely Souza E, et al. Mol Microbiol. 2022 Feb;117(2):293-306. doi: 10.1111/mmi.14844. Epub 2021 Dec 1. Mol Microbiol. 2022. PMID: 34783412 Free article.
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