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Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge.
Amaral MS, Santos DW, Pereira ASA, Tahira AC, Malvezzi JVM, Miyasato PA, Freitas RP, Kalil J, Tjon Kon Fat EM, de Dood CJ, Corstjens PLAM, van Dam GJ, Nakano E, Castro SO, Mattaraia VGM, Augusto RC, Grunau C, Wilson RA, Verjovski-Almeida S. Amaral MS, et al. Among authors: pereira asa. Nat Commun. 2021 Oct 26;12(1):6181. doi: 10.1038/s41467-021-26497-0. Nat Commun. 2021. PMID: 34702841 Free PMC article.
Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism.
Pereira ASA, Amaral MS, Vasconcelos EJR, Pires DS, Asif H, daSilva LF, Morales-Vicente DA, Carneiro VC, Angeli CB, Palmisano G, Fantappie MR, Pierce RJ, Setubal JC, Verjovski-Almeida S. Pereira ASA, et al. PLoS Negl Trop Dis. 2018 Oct 26;12(10):e0006873. doi: 10.1371/journal.pntd.0006873. eCollection 2018 Oct. PLoS Negl Trop Dis. 2018. PMID: 30365505 Free PMC article.
The antischistosomal potential of GSK-J4, an H3K27 demethylase inhibitor: insights from molecular modeling, transcriptomics and in vitro assays.
Lobo-Silva J, Cabral FJ, Amaral MS, Miyasato PA, de Freitas RP, Pereira ASA, Khouri MI, Barbosa MMF, Ramos PIP, Leite LCC, Asojo OA, Nakano E, Verjovski-Almeida S, Farias LP. Lobo-Silva J, et al. Among authors: pereira asa. Parasit Vectors. 2020 Mar 17;13(1):140. doi: 10.1186/s13071-020-4000-z. Parasit Vectors. 2020. PMID: 32178714 Free PMC article.
Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni.
Coutinho Carneiro V, de Abreu da Silva IC, Amaral MS, Pereira ASA, Silveira GO, Pires DDS, Verjovski-Almeida S, Dekker FJ, Rotili D, Mai A, Lopes-Torres EJ, Robaa D, Sippl W, Pierce RJ, Borrello MT, Ganesan A, Lancelot J, Thiengo S, Fernandez MA, Vicentino ARR, Mourão MM, Coelho FS, Fantappié MR. Coutinho Carneiro V, et al. Among authors: pereira asa. PLoS Negl Trop Dis. 2020 Jul 1;14(7):e0008332. doi: 10.1371/journal.pntd.0008332. eCollection 2020 Jul. PLoS Negl Trop Dis. 2020. PMID: 32609727 Free PMC article.
Long non-coding RNAs are essential for Schistosoma mansoni pairing-dependent adult worm homeostasis and fertility.
Silveira GO, Coelho HS, Pereira ASA, Miyasato PA, Santos DW, Maciel LF, Olberg GGG, Tahira AC, Nakano E, Oliveira MLS, Amaral MS, Verjovski-Almeida S. Silveira GO, et al. Among authors: pereira asa. PLoS Pathog. 2023 May 5;19(5):e1011369. doi: 10.1371/journal.ppat.1011369. eCollection 2023 May. PLoS Pathog. 2023. PMID: 37146077 Free PMC article.
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