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High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program.
Federici M, Hribal M, Perego L, Ranalli M, Caradonna Z, Perego C, Usellini L, Nano R, Bonini P, Bertuzzi F, Marlier LN, Davalli AM, Carandente O, Pontiroli AE, Melino G, Marchetti P, Lauro R, Sesti G, Folli F. Federici M, et al. Among authors: perego c, perego l. Diabetes. 2001 Jun;50(6):1290-301. doi: 10.2337/diabetes.50.6.1290. Diabetes. 2001. PMID: 11375329
Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans.
Hribal ML, Perego L, Lovari S, Andreozzi F, Menghini R, Perego C, Finzi G, Usellini L, Placidi C, Capella C, Guzzi V, Lauro D, Bertuzzi F, Davalli A, Pozza G, Pontiroli A, Federici M, Lauro R, Brunetti A, Folli F, Sesti G. Hribal ML, et al. Among authors: perego c, perego l. FASEB J. 2003 Jul;17(10):1340-2. doi: 10.1096/fj.02-0685fje. Epub 2003 May 8. FASEB J. 2003. PMID: 12738810
Disproportionate hyperproinsulinemia, beta-cell restricted prohormone convertase 2 deficiency, and cell cycle inhibitors expression by human islets transplanted into athymic nude mice: insights into nonimmune-mediated mechanisms of delayed islet graft failure.
Davalli AM, Perego L, Bertuzzi F, Finzi G, La Rosa S, Blau A, Placidi C, Nano R, Gregorini L, Perego C, Capella C, Folli F. Davalli AM, et al. Among authors: perego c, perego l. Cell Transplant. 2008;17(12):1323-36. doi: 10.3727/096368908787648137. Cell Transplant. 2008. PMID: 19364070 Free article.
Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons.
Guardado-Mendoza R, Davalli AM, Chavez AO, Hubbard GB, Dick EJ, Majluf-Cruz A, Tene-Perez CE, Goldschmidt L, Hart J, Perego C, Comuzzie AG, Tejero ME, Finzi G, Placidi C, La Rosa S, Capella C, Halff G, Gastaldelli A, DeFronzo RA, Folli F. Guardado-Mendoza R, et al. Among authors: perego c. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13992-7. doi: 10.1073/pnas.0906471106. Epub 2009 Jul 30. Proc Natl Acad Sci U S A. 2009. PMID: 19666551 Free PMC article.
The glial glutamate transporter 1 (GLT1) is expressed by pancreatic beta-cells and prevents glutamate-induced beta-cell death.
Di Cairano ES, Davalli AM, Perego L, Sala S, Sacchi VF, La Rosa S, Finzi G, Placidi C, Capella C, Conti P, Centonze VE, Casiraghi F, Bertuzzi F, Folli F, Perego C. Di Cairano ES, et al. Among authors: perego c, perego l. J Biol Chem. 2011 Apr 22;286(16):14007-18. doi: 10.1074/jbc.M110.183517. Epub 2011 Feb 18. J Biol Chem. 2011. PMID: 21335552 Free PMC article.
Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus.
Folli F, Okada T, Perego C, Gunton J, Liew CW, Akiyama M, D'Amico A, La Rosa S, Placidi C, Lupi R, Marchetti P, Sesti G, Hellerstein M, Perego L, Kulkarni RN. Folli F, et al. Among authors: perego c, perego l. PLoS One. 2011;6(11):e28050. doi: 10.1371/journal.pone.0028050. Epub 2011 Nov 30. PLoS One. 2011. PMID: 22140505 Free PMC article.
215 results