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A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better.
Djureinovic D, Weiss SA, Krykbaeva I, Qu R, Vathiotis I, Moutafi M, Zhang L, Perdigoto AL, Wei W, Anderson G, Damsky W, Hurwitz M, Johnson B, Schoenfeld D, Mahajan A, Hsu F, Miller-Jensen K, Kluger Y, Sznol M, Kaech SM, Bosenberg M, Jilaveanu LB, Kluger HM. Djureinovic D, et al. Among authors: perdigoto al. Mol Cancer. 2023 Nov 14;22(1):182. doi: 10.1186/s12943-023-01884-x. Mol Cancer. 2023. PMID: 37964379 Free PMC article.
Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors.
Stamatouli AM, Quandt Z, Perdigoto AL, Clark PL, Kluger H, Weiss SA, Gettinger S, Sznol M, Young A, Rushakoff R, Lee J, Bluestone JA, Anderson M, Herold KC. Stamatouli AM, et al. Among authors: perdigoto al. Diabetes. 2018 Aug;67(8):1471-1480. doi: 10.2337/dbi18-0002. Epub 2018 Jun 24. Diabetes. 2018. PMID: 29937434 Free PMC article. Review.
Adverse events induced by immune checkpoint inhibitors.
Perdigoto AL, Kluger H, Herold KC. Perdigoto AL, et al. Curr Opin Immunol. 2021 Apr;69:29-38. doi: 10.1016/j.coi.2021.02.002. Epub 2021 Feb 25. Curr Opin Immunol. 2021. PMID: 33640598 Free PMC article. Review.
Immune cells and their inflammatory mediators modify β cells and cause checkpoint inhibitor-induced diabetes.
Perdigoto AL, Deng S, Du KC, Kuchroo M, Burkhardt DB, Tong A, Israel G, Robert ME, Weisberg SP, Kirkiles-Smith N, Stamatouli AM, Kluger HM, Quandt Z, Young A, Yang ML, Mamula MJ, Pober JS, Anderson MS, Krishnaswamy S, Herold KC. Perdigoto AL, et al. JCI Insight. 2022 Sep 8;7(17):e156330. doi: 10.1172/jci.insight.156330. JCI Insight. 2022. PMID: 35925682 Free PMC article.
Germline genetic variants are associated with development of insulin-dependent diabetes in cancer patients treated with immune checkpoint inhibitors.
Caulfield JI, Aizenbud L, Perdigoto AL, Meffre E, Jilaveanu L, Michalek DA, Rich SS, Aizenbud Y, Adeniran A, Herold KC, Austin MR, Kluger H. Caulfield JI, et al. Among authors: perdigoto al. J Immunother Cancer. 2023 Mar;11(3):e006570. doi: 10.1136/jitc-2022-006570. J Immunother Cancer. 2023. PMID: 36898736 Free PMC article.
Response to "NLRC5 germline variants and their potential role in eliciting an immune response in patients with cancer treated with immune checkpoint inhibitors" by Xiang-Yu Meng.
Aizenbud L, Schoenfeld DA, Caulfield JI, Mann JE, Austin MR, Perdigoto AL, Herold KC, Kluger HM. Aizenbud L, et al. Among authors: perdigoto al. J Immunother Cancer. 2023 Jun;11(6):e007397. doi: 10.1136/jitc-2023-007397. J Immunother Cancer. 2023. PMID: 37349129 Free PMC article. No abstract available.
Have we pushed the needle for treatment of Type 1 diabetes?
Naushad N, Perdigoto AL, Rui J, Herold KC. Naushad N, et al. Among authors: perdigoto al. Curr Opin Immunol. 2017 Dec;49:44-50. doi: 10.1016/j.coi.2017.09.004. Epub 2017 Oct 6. Curr Opin Immunol. 2017. PMID: 28992525 Free PMC article. Review.
30 results