A core folding model for catalysis by the hammerhead ribozyme accounts for its extraordinary sensitivity to abasic mutations.
Peracchi A, Karpeisky A, Maloney L, Beigelman L, Herschlag D.
Peracchi A, et al.
Biochemistry. 1998 Oct 20;37(42):14765-75. doi: 10.1021/bi980867y.
Biochemistry. 1998.
PMID: 9778351
Introducing abasic nucleotides at each of 13 positions in the conserved core of the hammerhead ribozyme causes a large decrease in the extent of catalysis [Peracchi, A., et al. (1996) Proc. ...This behavior represents a basic manifestation of the well- …
Introducing abasic nucleotides at each of 13 positions in the conserved core of the hammerhead ribozyme causes a large decrease in th …