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The silence of the fats: A MAM's story about Alzheimer.
Agrawal RR, Montesinos J, Larrea D, Area-Gomez E, Pera M. Agrawal RR, et al. Among authors: pera m. Neurobiol Dis. 2020 Nov;145:105062. doi: 10.1016/j.nbd.2020.105062. Epub 2020 Aug 29. Neurobiol Dis. 2020. PMID: 32866617 Free article. Review.
Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.
Pera M, Larrea D, Guardia-Laguarta C, Montesinos J, Velasco KR, Agrawal RR, Xu Y, Chan RB, Di Paolo G, Mehler MF, Perumal GS, Macaluso FP, Freyberg ZZ, Acin-Perez R, Enriquez JA, Schon EA, Area-Gomez E. Pera M, et al. EMBO J. 2017 Nov 15;36(22):3356-3371. doi: 10.15252/embj.201796797. Epub 2017 Oct 10. EMBO J. 2017. PMID: 29018038 Free PMC article.
MAM and C99, key players in the pathogenesis of Alzheimer's disease.
Pera M, Montesinos J, Larrea D, Agrawal RR, Velasco KR, Stavrovskaya IG, Yun TD, Area-Gomez E. Pera M, et al. Int Rev Neurobiol. 2020;154:235-278. doi: 10.1016/bs.irn.2020.03.016. Epub 2020 Jul 22. Int Rev Neurobiol. 2020. PMID: 32739006 Review.
MFN2 mutations in Charcot-Marie-Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics.
Larrea D, Pera M, Gonnelli A, Quintana-Cabrera R, Akman HO, Guardia-Laguarta C, Velasco KR, Area-Gomez E, Dal Bello F, De Stefani D, Horvath R, Shy ME, Schon EA, Giacomello M. Larrea D, et al. Among authors: pera m. Hum Mol Genet. 2019 Jun 1;28(11):1782-1800. doi: 10.1093/hmg/ddz008. Hum Mol Genet. 2019. PMID: 30649465 Free PMC article.
ApoE4 upregulates the activity of mitochondria-associated ER membranes.
Tambini MD, Pera M, Kanter E, Yang H, Guardia-Laguarta C, Holtzman D, Sulzer D, Area-Gomez E, Schon EA. Tambini MD, et al. Among authors: pera m. EMBO Rep. 2016 Jan;17(1):27-36. doi: 10.15252/embr.201540614. Epub 2015 Nov 12. EMBO Rep. 2016. PMID: 26564908 Free PMC article.
Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface.
Guardia-Laguarta C, Coma M, Pera M, Clarimón J, Sereno L, Agulló JM, Molina-Porcel L, Gallardo E, Deng A, Berezovska O, Hyman BT, Blesa R, Gómez-Isla T, Lleó A. Guardia-Laguarta C, et al. Among authors: pera m. J Neurochem. 2009 Jul;110(1):220-30. doi: 10.1111/j.1471-4159.2009.06126.x. Epub 2009 Apr 27. J Neurochem. 2009. PMID: 19457132 Free PMC article.
673 results