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Emerging functions and clinical prospects of connexins and pannexins in melanoma.
Varela-Vázquez A, Guitián-Caamaño A, Carpintero-Fernandez P, Fonseca E, Sayedyahossein S, Aasen T, Penuela S, Mayán MD. Varela-Vázquez A, et al. Among authors: penuela s. Biochim Biophys Acta Rev Cancer. 2020 Aug;1874(1):188380. doi: 10.1016/j.bbcan.2020.188380. Epub 2020 May 24. Biochim Biophys Acta Rev Cancer. 2020. PMID: 32461135 Free article. Review.
The biochemistry and function of pannexin channels.
Penuela S, Gehi R, Laird DW. Penuela S, et al. Biochim Biophys Acta. 2013 Jan;1828(1):15-22. doi: 10.1016/j.bbamem.2012.01.017. Epub 2012 Jan 28. Biochim Biophys Acta. 2013. PMID: 22305965 Free article. Review.
Inhibition of Pannexin 1 Reduces the Tumorigenic Properties of Human Melanoma Cells.
Freeman TJ, Sayedyahossein S, Johnston D, Sanchez-Pupo RE, O'Donnell B, Huang K, Lakhani Z, Nouri-Nejad D, Barr KJ, Harland L, Latosinsky S, Grant A, Dagnino L, Penuela S. Freeman TJ, et al. Among authors: penuela s. Cancers (Basel). 2019 Jan 16;11(1):102. doi: 10.3390/cancers11010102. Cancers (Basel). 2019. PMID: 30654593 Free PMC article.
Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein.
Nouri-Nejad D, O'Donnell BL, Patil CS, Sanchez-Pupo RE, Johnston D, Sayedyahossein S, Jurcic K, Lau R, Gyenis L, Litchfield DW, Jackson MF, Gloor GB, Penuela S. Nouri-Nejad D, et al. Among authors: penuela s. Mol Biol Cell. 2021 Mar 1;32(5):376-390. doi: 10.1091/mbc.E19-10-0585. Epub 2021 Jan 6. Mol Biol Cell. 2021. PMID: 33405952 Free PMC article.
Pannexin 1 binds β-catenin to modulate melanoma cell growth and metabolism.
Sayedyahossein S, Huang K, Li Z, Zhang C, Kozlov AM, Johnston D, Nouri-Nejad D, Dagnino L, Betts DH, Sacks DB, Penuela S. Sayedyahossein S, et al. Among authors: penuela s. J Biol Chem. 2021 Jan-Jun;296:100478. doi: 10.1016/j.jbc.2021.100478. Epub 2021 Feb 26. J Biol Chem. 2021. PMID: 33647315 Free PMC article.
Pannexin biology and emerging linkages to cancer.
Laird DW, Penuela S. Laird DW, et al. Among authors: penuela s. Trends Cancer. 2021 Dec;7(12):1119-1131. doi: 10.1016/j.trecan.2021.07.002. Epub 2021 Aug 11. Trends Cancer. 2021. PMID: 34389277 Review.
Pannexin 3 deletion reduces fat accumulation and inflammation in a sex-specific manner.
Wakefield CB, Lee VR, Johnston D, Boroumand P, Pillon NJ, Sayedyahossein S, O'Donnell BL, Tang J, Sanchez-Pupo RE, Barr KJ, Gros R, Flynn L, Borradaile NM, Klip A, Beier F, Penuela S. Wakefield CB, et al. Among authors: penuela s. Int J Obes (Lond). 2022 Apr;46(4):726-738. doi: 10.1038/s41366-021-01037-4. Epub 2021 Dec 13. Int J Obes (Lond). 2022. PMID: 34897286
70 results