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Page 1
Mast cell-derived BH4 is a critical mediator of postoperative pain.
Starkl P, Jonsson G, Artner T, Turnes BL, Serhan N, Oliveira T, Gail LM, Stejskal K, Channon KM, Köcher T, Stary G, Klang V, Gaudenzio N, Knapp S, Woolf CJ, Penninger JM, Cronin SJF. Starkl P, et al. Among authors: penninger jm. bioRxiv [Preprint]. 2023 Jan 24:2023.01.24.525378. doi: 10.1101/2023.01.24.525378. bioRxiv. 2023. PMID: 37293068 Free PMC article. Preprint.
Development of a novel, pan-variant aerosol intervention for COVID-19.
Shoemaker RH, Panettieri RA Jr, Libutti SK, Hochster HS, Watts NR, Wingfield PT, Starkl P, Pimenov L, Gawish R, Hladik A, Knapp S, Boring D, White JM, Lawrence Q, Boone J, Marshall JD, Matthews RL, Cholewa BD, Richig JW, Chen BT, McCormick DL, Gugensberger R, Höller S, Penninger JM, Wirnsberger G. Shoemaker RH, et al. Among authors: penninger jm. bioRxiv [Preprint]. 2021 Sep 20:2021.09.14.459961. doi: 10.1101/2021.09.14.459961. bioRxiv. 2021. PMID: 34545364 Free PMC article. Updated. Preprint.
Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons.
Cronin SJF, Yu W, Hale A, Licht-Mayer S, Crabtree MJ, Korecka JA, Tretiakov EO, Sealey-Cardona M, Somlyay M, Onji M, An M, Fox JD, Turnes BL, Gomez-Diaz C, da Luz Scheffer D, Cikes D, Nagy V, Weidinger A, Wolf A, Reither H, Chabloz A, Kavirayani A, Rao S, Andrews N, Latremoliere A, Costigan M, Douglas G, Freitas FC, Pifl C, Walz R, Konrat R, Mahad DJ, Koslov AV, Latini A, Isacson O, Harkany T, Hallett PJ, Bagby S, Woolf CJ, Channon KM, Je HS, Penninger JM. Cronin SJF, et al. Among authors: penninger jm. bioRxiv [Preprint]. 2023 May 8:2023.05.08.539795. doi: 10.1101/2023.05.08.539795. bioRxiv. 2023. PMID: 37214873 Free PMC article. Preprint.
Pseudorabies virus hijacks DDX3X, initiating an addictive "mad itch" and immune suppression, to facilitate viral spread.
Cronin SJF, Tejada MA, Song R, Laval K, Cikes D, Ji M, Brai A, Stadlmann J, Novatchikova M, Perlot T, Ali OH, Botta L, Decker T, Lazovic J, Hagelkruys A, Enquist L, Rao S, Koyuncu OO, Penninger JM. Cronin SJF, et al. Among authors: penninger jm. bioRxiv [Preprint]. 2023 May 9:2023.05.09.539956. doi: 10.1101/2023.05.09.539956. bioRxiv. 2023. PMID: 37214906 Free PMC article. Preprint.
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants.
Wirnsberger G, Monteil V, Eaton B, Postnikova E, Murphy M, Braunsfeld B, Crozier I, Kricek F, Niederhöfer J, Schwarzböck A, Breid H, Jimenez AS, Bugajska-Schretter A, Dohnal A, Ruf C, Gugenberger R, Hagelkruys A, Montserrat N, Holbrook MR, Oostenbrink C, Shoemaker RH, Mirazimi A, Penninger JM. Wirnsberger G, et al. Among authors: penninger jm. bioRxiv [Preprint]. 2021 Sep 10:2021.09.10.459744. doi: 10.1101/2021.09.10.459744. bioRxiv. 2021. PMID: 34545368 Free PMC article. Updated. Preprint.
Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells.
Monteil VM, Wright SC, Dyczynski M, Kellner MJ, Appelberg S, Platzer SW, Ibrahim A, Kwon H, Pittarokoilis I, Mirandola M, Michlits G, Devignot S, Elder E, Abdurahman S, Bereczky S, Bagci B, Youhanna S, Aastrup T, Lauschke VM, Salata C, Elaldi N, Weber F, Monserrat N, Hawman DW, Feldmann H, Horn M, Penninger JM, Mirazimi A. Monteil VM, et al. Among authors: penninger jm. Nat Microbiol. 2024 Mar 28. doi: 10.1038/s41564-024-01672-3. Online ahead of print. Nat Microbiol. 2024. PMID: 38548922
Generation of complex bone marrow organoids from human induced pluripotent stem cells.
Frenz-Wiessner S, Fairley SD, Buser M, Goek I, Salewskij K, Jonsson G, Illig D, Zu Putlitz B, Petersheim D, Li Y, Chen PH, Kalauz M, Conca R, Sterr M, Geuder J, Mizoguchi Y, Megens RTA, Linder MI, Kotlarz D, Rudelius M, Penninger JM, Marr C, Klein C. Frenz-Wiessner S, et al. Among authors: penninger jm. Nat Methods. 2024 Feb 19. doi: 10.1038/s41592-024-02172-2. Online ahead of print. Nat Methods. 2024. PMID: 38374263
A microfluidic platform integrating functional vascularized organoids-on-chip.
Quintard C, Tubbs E, Jonsson G, Jiao J, Wang J, Werschler N, Laporte C, Pitaval A, Bah TS, Pomeranz G, Bissardon C, Kaal J, Leopoldi A, Long DA, Blandin P, Achard JL, Battail C, Hagelkruys A, Navarro F, Fouillet Y, Penninger JM, Gidrol X. Quintard C, et al. Among authors: penninger jm. Nat Commun. 2024 Feb 16;15(1):1452. doi: 10.1038/s41467-024-45710-4. Nat Commun. 2024. PMID: 38365780 Free PMC article.
Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism.
Cikes D, Leutner M, Cronin SJF, Novatchkova M, Pfleger L, Klepochová R, Lair B, Lac M, Bergoglio C, Viguerie N, Dürnberger G, Roitinger E, Grivej M, Rullman E, Gustafsson T, Hagelkruys A, Tavernier G, Bourlier V, Knauf C, Krebs M, Kautzky-Willer A, Moro C, Krssak M, Orthofer M, Penninger JM. Cikes D, et al. Among authors: penninger jm. Nat Aging. 2024 Jan;4(1):80-94. doi: 10.1038/s43587-023-00551-6. Epub 2024 Jan 18. Nat Aging. 2024. PMID: 38238601
563 results