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HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases.
Kogler M, Tortola L, Negri GL, Leopoldi A, El-Naggar AM, Mereiter S, Gomez-Diaz C, Nitsch R, Tortora D, Kavirayani AM, Gapp BV, Rao S, Uribesalgo I, Hoffmann D, Cikes D, Novatchkova M, Williams DA, Trent JM, Ikeda F, Daugaard M, Hagelkruys A, Sorensen PH, Penninger JM. Kogler M, et al. Among authors: penninger jm. Cancer Res. 2020 Jul 15;80(14):3009-3022. doi: 10.1158/0008-5472.CAN-19-2270. Epub 2020 May 4. Cancer Res. 2020. PMID: 32366477 Free PMC article.
Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes.
Daugaard M, Nitsch R, Razaghi B, McDonald L, Jarrar A, Torrino S, Castillo-Lluva S, Rotblat B, Li L, Malliri A, Lemichez E, Mettouchi A, Berman JN, Penninger JM, Sorensen PH. Daugaard M, et al. Among authors: penninger jm. Nat Commun. 2013;4:2180. doi: 10.1038/ncomms3180. Nat Commun. 2013. PMID: 23864022 Free PMC article.
A dual role for autophagy in a murine model of lung cancer.
Rao S, Tortola L, Perlot T, Wirnsberger G, Novatchkova M, Nitsch R, Sykacek P, Frank L, Schramek D, Komnenovic V, Sigl V, Aumayr K, Schmauss G, Fellner N, Handschuh S, Glösmann M, Pasierbek P, Schlederer M, Resch GP, Ma Y, Yang H, Popper H, Kenner L, Kroemer G, Penninger JM. Rao S, et al. Among authors: penninger jm. Nat Commun. 2014;5:3056. doi: 10.1038/ncomms4056. Nat Commun. 2014. PMID: 24445999 Free article.
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
Rotblat B, Southwell AL, Ehrnhoefer DE, Skotte NH, Metzler M, Franciosi S, Leprivier G, Somasekharan SP, Barokas A, Deng Y, Tang T, Mathers J, Cetinbas N, Daugaard M, Kwok B, Li L, Carnie CJ, Fink D, Nitsch R, Galpin JD, Ahern CA, Melino G, Penninger JM, Hayden MR, Sorensen PH. Rotblat B, et al. Among authors: penninger jm. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3032-7. doi: 10.1073/pnas.1314421111. Epub 2014 Feb 10. Proc Natl Acad Sci U S A. 2014. PMID: 24516159 Free PMC article.
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.
Paolino M, Choidas A, Wallner S, Pranjic B, Uribesalgo I, Loeser S, Jamieson AM, Langdon WY, Ikeda F, Fededa JP, Cronin SJ, Nitsch R, Schultz-Fademrecht C, Eickhoff J, Menninger S, Unger A, Torka R, Gruber T, Hinterleitner R, Baier G, Wolf D, Ullrich A, Klebl BM, Penninger JM. Paolino M, et al. Among authors: penninger jm. Nature. 2014 Mar 27;507(7493):508-12. doi: 10.1038/nature12998. Epub 2014 Feb 19. Nature. 2014. PMID: 24553136 Free PMC article.
634 results