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Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists.
Yrjölä S, Parkkari T, Navia-Paldanius D, Laitinen T, Kaczor AA, Kokkola T, Adusei-Mensah F, Savinainen JR, Laitinen JT, Poso A, Alexander A, Penman J, Stott L, Anskat M, Irving AJ, Nevalainen TJ. Yrjölä S, et al. Among authors: penman j. Eur J Med Chem. 2016 Jan 1;107:119-32. doi: 10.1016/j.ejmech.2015.10.050. Epub 2015 Nov 2. Eur J Med Chem. 2016. PMID: 26575458
GPR55 ligands promote receptor coupling to multiple signalling pathways.
Henstridge CM, Balenga NA, Schröder R, Kargl JK, Platzer W, Martini L, Arthur S, Penman J, Whistler JL, Kostenis E, Waldhoer M, Irving AJ. Henstridge CM, et al. Among authors: penman j. Br J Pharmacol. 2010 Jun;160(3):604-14. doi: 10.1111/j.1476-5381.2009.00625.x. Epub 2010 Feb 5. Br J Pharmacol. 2010. PMID: 20136841 Free PMC article.
Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors.
Irving A, Abdulrazzaq G, Chan SLF, Penman J, Harvey J, Alexander SPH. Irving A, et al. Among authors: penman j. Adv Pharmacol. 2017;80:223-247. doi: 10.1016/bs.apha.2017.04.004. Epub 2017 Jun 12. Adv Pharmacol. 2017. PMID: 28826536 Review.
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group; Horby PW, Peto L, Staplin N, Campbell M, Pessoa-Amorim G, Mafham M, Emberson JR, Stewart R, Prudon B, Uriel A, Green CA, Dhasmana DJ, Malein F, Majumdar J, Collini P, Shurmer J, Yates B, Baillie JK, Buch MH, Day J, Faust SN, Jaki T, Jeffery K, Juszczak E, Knight M, Lim WS, Montgomery A, Mumford A, Rowan K, Thwaites G, Haynes R, Landray MJ. RECOVERY Collaborative Group, et al. Nat Commun. 2024 Jan 31;15(1):924. doi: 10.1038/s41467-023-43644-x. Nat Commun. 2024. PMID: 38296965 Free PMC article. Clinical Trial.
80 results