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Page 1
Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance.
Gauttier V, Pengam S, Durand J, Biteau K, Mary C, Morello A, Néel M, Porto G, Teppaz G, Thepenier V, Danger R, Vince N, Wilhelm E, Girault I, Abes R, Ruiz C, Trilleaud C, Ralph K, Trombetta ES, Garcia A, Vignard V, Martinet B, Glémain A, Bruneau S, Haspot F, Dehmani S, Duplouye P, Miyasaka M, Labarrière N, Laplaud D, Le Bas-Bernardet S, Blanquart C, Catros V, Gouraud PA, Archambeaud I, Aublé H, Metairie S, Mosnier JF, Costantini D, Blancho G, Conchon S, Vanhove B, Poirier N. Gauttier V, et al. Among authors: pengam s. J Clin Invest. 2020 Nov 2;130(11):6109-6123. doi: 10.1172/JCI135528. J Clin Invest. 2020. PMID: 33074246 Free PMC article.
FR104, an antagonist anti-CD28 monovalent fab' antibody, prevents alloimmunization and allows calcineurin inhibitor minimization in nonhuman primate renal allograft.
Poirier N, Dilek N, Mary C, Ville S, Coulon F, Branchereau J, Tillou X, Charpy V, Pengam S, Nerriere-Daguin V, Hervouet J, Minault D, Le Bas-Bernardet S, Renaudin K, Vanhove B, Blancho G. Poirier N, et al. Among authors: pengam s. Am J Transplant. 2015 Jan;15(1):88-100. doi: 10.1111/ajt.12964. Epub 2014 Dec 8. Am J Transplant. 2015. PMID: 25488654 Free article.
Anti-CD28 Antibody and Belatacept Exert Differential Effects on Mechanisms of Renal Allograft Rejection.
Ville S, Poirier N, Branchereau J, Charpy V, Pengam S, Nerriere-Daguin V, Le Bas-Bernardet S, Coulon F, Mary C, Chenouard A, Hervouet J, Minault D, Nedellec S, Renaudin K, Vanhove B, Blancho G. Ville S, et al. Among authors: pengam s. J Am Soc Nephrol. 2016 Dec;27(12):3577-3588. doi: 10.1681/ASN.2015070774. Epub 2016 May 9. J Am Soc Nephrol. 2016. PMID: 27160407 Free PMC article.
IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates.
Belarif L, Mary C, Jacquemont L, Mai HL, Danger R, Hervouet J, Minault D, Thepenier V, Nerrière-Daguin V, Nguyen E, Pengam S, Largy E, Delobel A, Martinet B, Le Bas-Bernardet S, Brouard S, Soulillou JP, Degauque N, Blancho G, Vanhove B, Poirier N. Belarif L, et al. Among authors: pengam s. Nat Commun. 2018 Oct 26;9(1):4483. doi: 10.1038/s41467-018-06804-y. Nat Commun. 2018. PMID: 30367166 Free PMC article.
IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease.
Belarif L, Danger R, Kermarrec L, Nerrière-Daguin V, Pengam S, Durand T, Mary C, Kerdreux E, Gauttier V, Kucik A, Thepenier V, Martin JC, Chang C, Rahman A, Guen NS, Braudeau C, Abidi A, David G, Malard F, Takoudju C, Martinet B, Gérard N, Neveu I, Neunlist M, Coron E, MacDonald TT, Desreumaux P, Mai HL, Le Bas-Bernardet S, Mosnier JF, Merad M, Josien R, Brouard S, Soulillou JP, Blancho G, Bourreille A, Naveilhan P, Vanhove B, Poirier N. Belarif L, et al. Among authors: pengam s. J Clin Invest. 2019 Apr 2;129(5):1910-1925. doi: 10.1172/JCI121668. eCollection 2019 Apr 2. J Clin Invest. 2019. PMID: 30939120 Free PMC article.
Interleukin-7/Interferon Axis Drives T Cell and Salivary Gland Epithelial Cell Interactions in Sjögren's Syndrome.
Rivière E, Pascaud J, Virone A, Dupré A, Ly B, Paoletti A, Seror R, Tchitchek N, Mingueneau M, Smith N, Duffy D, Cassard L, Chaput N, Pengam S, Gauttier V, Poirier N, Mariette X, Nocturne G. Rivière E, et al. Among authors: pengam s. Arthritis Rheumatol. 2021 Apr;73(4):631-640. doi: 10.1002/art.41558. Epub 2021 Feb 15. Arthritis Rheumatol. 2021. PMID: 33058491
Agonist anti-ChemR23 mAb reduces tissue neutrophil accumulation and triggers chronic inflammation resolution.
Trilleaud C, Gauttier V, Biteau K, Girault I, Belarif L, Mary C, Pengam S, Teppaz G, Thepenier V, Danger R, Robert-Siegwald G, Néel M, Bruneau S, Glémain A, Néel A, Poupon A, Mosnier JF, Chêne G, Dubourdeau M, Blancho G, Vanhove B, Poirier N. Trilleaud C, et al. Among authors: pengam s. Sci Adv. 2021 Apr 2;7(14):eabd1453. doi: 10.1126/sciadv.abd1453. Print 2021 Apr. Sci Adv. 2021. PMID: 33811066 Free PMC article.
Concerted BAG3 and SIRPα blockade impairs pancreatic tumor growth.
De Marco M, Gauttier V, Pengam S, Mary C, Ranieri B, Basile A, Festa M, Falco A, Reppucci F, Cammarota AL, Acernese F, De Laurenzi V, Sala G, Brongo S, Miyasaka M, Shalapour S, Vanhove B, Poirier N, Iaccarino R, Karin M, Turco MC, Rosati A, Marzullo L. De Marco M, et al. Among authors: pengam s. Cell Death Discov. 2022 Mar 3;8(1):94. doi: 10.1038/s41420-022-00817-9. Cell Death Discov. 2022. PMID: 35241649 Free PMC article.
CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy.
Drouin M, Saenz J, Gauttier V, Evrard B, Teppaz G, Pengam S, Mary C, Desselle A, Thepenier V, Wilhelm E, Merieau E, Ligeron C, Girault I, Lopez MD, Fourgeux C, Sinha D, Baccelli I, Moreau A, Louvet C, Josien R, Poschmann J, Poirier N, Chiffoleau E. Drouin M, et al. Among authors: pengam s. Sci Adv. 2022 Nov 16;8(46):eabo7621. doi: 10.1126/sciadv.abo7621. Epub 2022 Nov 18. Sci Adv. 2022. PMID: 36399563 Free PMC article.
12 results