Peng Y - Search Results

1

Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.

Meng Y, Yu B, Huang H, Peng Y, Li E, Yao Y, Song C, Yu W, Zhu K, Wang K, Yi D, Du J, Chang J. Meng Y, et al. Among authors: peng y. J Med Chem. 2021 Jan 28;64(2):925-937. doi: 10.1021/acs.jmedchem.0c02005. Epub 2021 Jan 18. J Med Chem. 2021. PMID: 33459024

2

Quantification of 2'-deoxy-2'-β-fluoro-4'-azidocytidine in rat and dog plasma using liquid chromatography-quadrupole time-of-flight and liquid chromatography-triple quadrupole mass spectrometry: Application to bioavailability and pharmacokinetic studies.

Peng Y, Cheng T, Dong L, Zhang Y, Chen X, Jiang J, Zhang J, Guo X, Guo M, Chang J, Wang Q. Peng Y, et al. J Pharm Biomed Anal. 2014 Sep;98:379-86. doi: 10.1016/j.jpba.2014.06.019. Epub 2014 Jun 20. J Pharm Biomed Anal. 2014. PMID: 24999865

3

Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro.

Wang RR, Yang QH, Luo RH, Peng YM, Dai SX, Zhang XJ, Chen H, Cui XQ, Liu YJ, Huang JF, Chang JB, Zheng YT. Wang RR, et al. PLoS One. 2014 Aug 21;9(8):e105617. doi: 10.1371/journal.pone.0105617. eCollection 2014. PLoS One. 2014. PMID: 25144636 Free PMC article.

4

Synthesis and biological evaluation of 4-substituted fluoronucleoside analogs for the treatment of hepatitis B virus infection.

Yang Q, Kang J, Zheng L, Wang XJ, Wan N, Wu J, Qiao Y, Niu P, Wang SQ, Peng Y, Wang Q, Yu W, Chang J. Yang Q, et al. Among authors: peng y. J Med Chem. 2015 May 14;58(9):3693-703. doi: 10.1021/jm5012963. Epub 2015 May 4. J Med Chem. 2015. PMID: 25905540

5

Design, synthesis, and biological evaluation of new N(4)-Substituted 2'-deoxy-2'-fluoro-4'-azido cytidine derivatives as potent anti-HBV agents.

Lv Z, He W, Tian X, Kang J, Liu Y, Peng Y, Zheng L, Wang Q, Yu W, Chang J. Lv Z, et al. Among authors: peng y. Eur J Med Chem. 2015 Aug 28;101:103-10. doi: 10.1016/j.ejmech.2015.06.030. Epub 2015 Jun 22. Eur J Med Chem. 2015. PMID: 26119991

6

Discovery of an Orally Active and Liver-Targeted Prodrug of 5-Fluoro-2'-Deoxyuridine for the Treatment of Hepatocellular Carcinoma.

Peng Y, Yu W, Li E, Kang J, Wang Y, Yang Q, Liu B, Zhang J, Li L, Wu J, Jiang J, Wang Q, Chang J. Peng Y, et al. J Med Chem. 2016 Apr 28;59(8):3661-70. doi: 10.1021/acs.jmedchem.5b01807. Epub 2016 Apr 6. J Med Chem. 2016. PMID: 27022837

7

FNC efficiently inhibits mantle cell lymphoma growth.

Zhang Y, Zhang R, Ding X, Peng B, Wang N, Ma F, Peng Y, Wang Q, Chang J. Zhang Y, et al. Among authors: peng b, peng y. PLoS One. 2017 Mar 23;12(3):e0174112. doi: 10.1371/journal.pone.0174112. eCollection 2017. PLoS One. 2017. PMID: 28333959 Free PMC article.

8

Intestinal absorption mechanisms of 2'-deoxy-2'-β-fluoro-4'-azidocytidine, a cytidine analog for AIDS treatment, and its interaction with P-glycoprotein, multidrug resistance-associated protein 2 and breast cancer resistance protein.

Liu Y, Liu B, Zhang Y, Peng Y, Huang C, Wang N, Jiang J, Wang Q, Chang J. Liu Y, et al. Among authors: peng y. Eur J Pharm Sci. 2017 Jul 15;105:150-158. doi: 10.1016/j.ejps.2017.05.009. Epub 2017 May 6. Eur J Pharm Sci. 2017. PMID: 28487144

9

Synthesis and biological evaluation of a novel β-D-2'-deoxy-2'-α-fluoro-2'-β-C-(fluoromethyl)uridine phosphoramidate prodrug for the treatment of hepatitis C virus infection.

Li E, Wang Y, Yu W, Lv Z, Peng Y, Liu B, Li S, Ho W, Wang Q, Li H, Chang J. Li E, et al. Among authors: peng y. Eur J Med Chem. 2018 Jan 1;143:107-113. doi: 10.1016/j.ejmech.2017.11.024. Epub 2017 Nov 9. Eur J Med Chem. 2018. PMID: 29172078

10

Design, synthesis, and biological evaluation of new 1,2,3-triazolo-2'-deoxy-2'-fluoro- 4'-azido nucleoside derivatives as potent anti-HBV agents.

Liu Y, Peng Y, Lu J, Wang J, Ma H, Song C, Liu B, Qiao Y, Yu W, Wu J, Chang J. Liu Y, et al. Among authors: peng y. Eur J Med Chem. 2018 Jan 1;143:137-149. doi: 10.1016/j.ejmech.2017.11.028. Epub 2017 Nov 10. Eur J Med Chem. 2018. PMID: 29174810

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