Interleukin-1 receptor antagonist protein (IL-1Ra) and miR-140 overexpression via pNNS-conjugated chitosan-mediated gene transfer enhances the repair of full-thickness cartilage defects in a rabbit model.
Zhao R, Wang S, Jia L, Li Q, Qiao J, Peng X.
Zhao R, et al. Among authors: peng x.
Bone Joint Res. 2019 Apr 2;8(3):165-178. doi: 10.1302/2046-3758.83.BJR-2018-0222.R1. eCollection 2019 Mar.
Bone Joint Res. 2019.
PMID: 30997042
Free PMC article.
CONCLUSION: This study suggests that pNNS-CS is a good candidate for treating cartilage defects via gene therapy, and that IL-1Ra in combination with miR-140 produces promising biological effects on cartilage defects.Cite this article: R. Zhao, S. Wang, L. Jia, Q. Li, J. Qiao, …
CONCLUSION: This study suggests that pNNS-CS is a good candidate for treating cartilage defects via gene therapy, and that IL-1Ra in combina …