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The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.
Maurer MF, Lewis KE, Kuijper JL, Ardourel D, Gudgeon CJ, Chandrasekaran S, Mudri SL, Kleist KN, Navas C, Wolfson MF, Rixon MW, Swanson R, Dillon SR, Levin SD, Kimbung YR, Akutsu M, Logan DT, Walse B, Swiderek KM, Peng SL. Maurer MF, et al. Among authors: peng sl. Nat Commun. 2022 Apr 4;13(1):1790. doi: 10.1038/s41467-022-29286-5. Nat Commun. 2022. PMID: 35379805 Free PMC article.
Novel Immunomodulatory Proteins Generated via Directed Evolution of Variant IgSF Domains.
Levin SD, Evans LS, Bort S, Rickel E, Lewis KE, Wu RP, Hoover J, MacNeil S, La D, Wolfson MF, Rixon MW, Dillon SR, Kornacker MG, Swanson R, Peng SL. Levin SD, et al. Among authors: peng sl. Front Immunol. 2020 Jan 21;10:3086. doi: 10.3389/fimmu.2019.03086. eCollection 2019. Front Immunol. 2020. PMID: 32038630 Free PMC article.
ICOSL+ plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist.
Adom D, Dillon SR, Yang J, Liu H, Ramadan A, Kushekhar K, Hund S, Albright A, Kirksey M, Adeniyan T, Lewis KE, Evans L, Wu R, Levin SD, Mudri S, Yang J, Rickel E, Seaberg M, Henderson K, Gudgeon CJ, Wolfson MF, Swanson RM, Swiderek KM, Peng SL, Hippen KL, Blazar BR, Paczesny S. Adom D, et al. Among authors: peng sl. Sci Transl Med. 2020 Oct 7;12(564):eaay4799. doi: 10.1126/scitranslmed.aay4799. Sci Transl Med. 2020. PMID: 33028709 Free PMC article.
Povetacicept, an Enhanced Dual APRIL/BAFF Antagonist That Modulates B Lymphocytes and Pathogenic Autoantibodies for the Treatment of Lupus and Other B Cell-Related Autoimmune Diseases.
Evans LS, Lewis KE, DeMonte D, Bhandari JG, Garrett LB, Kuijper JL, Ardourel D, Wolfson MF, Debrot S, Mudri S, Kleist K, Griffin LL, Hebb L, Sanderson RJ, Wang N, Seaberg M, Chunyk AG, Yang J, Hong Y, Maria Z, Messenheimer DJ, Holland PM, Peng SL, Rixon MW, Dillon SR. Evans LS, et al. Among authors: peng sl. Arthritis Rheumatol. 2023 Jul;75(7):1187-1202. doi: 10.1002/art.42462. Epub 2023 Apr 19. Arthritis Rheumatol. 2023. PMID: 36705554
Non-Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN-101).
Dillon SR, Evans LS, Lewis KE, Debrot S, Blair TC, Mudri S, Kleist K, Levin SD, Bhandari JG, Garrett L, Wolfson MF, Holland PM, Rixon MW, Peng SL. Dillon SR, et al. Among authors: peng sl. Arthritis Rheumatol. 2023 Aug;75(8):1344-1356. doi: 10.1002/art.42484. Epub 2023 May 9. Arthritis Rheumatol. 2023. PMID: 36862144
First-in-human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN-101, a dual CD28/ICOS antagonist, in healthy adult subjects.
Yang J, Lickliter JD, Hillson JL, Means GD, Sanderson RJ, Carley K, Tercero A, Manjarrez KL, Wiley JR, Peng SL. Yang J, et al. Among authors: peng sl. Clin Transl Sci. 2021 Jul;14(4):1314-1326. doi: 10.1111/cts.12983. Epub 2021 Mar 2. Clin Transl Sci. 2021. PMID: 33503289 Free PMC article. Clinical Trial.
Colorectal cancer-specific IFNβ delivery overcomes dysfunctional dsRNA-mediated type I interferon signaling to increase the abscopal effect of radiotherapy.
Huang KC, Chiang SF, Chang HY, Hong WZ, Chen JY, Lee PC, Liang JA, Ke TW, Peng SL, Shiau AC, Chen TW, Yang PC, Chen WT, Chao KSC. Huang KC, et al. Among authors: peng sl. J Immunother Cancer. 2024 May 15;12(5):e008515. doi: 10.1136/jitc-2023-008515. J Immunother Cancer. 2024. PMID: 38749537 Free PMC article.
320 results