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AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue.
Pollard AE, Martins L, Muckett PJ, Khadayate S, Bornot A, Clausen M, Admyre T, Bjursell M, Fiadeiro R, Wilson L, Whilding C, Kotiadis VN, Duchen MR, Sutton D, Penfold L, Sardini A, Bohlooly-Y M, Smith DM, Read JA, Snowden MA, Woods A, Carling D. Pollard AE, et al. Among authors: penfold l. Nat Metab. 2019 Mar;1(3):340-349. doi: 10.1038/s42255-019-0036-9. Epub 2019 Feb 25. Nat Metab. 2019. PMID: 30887000 Free PMC article. No abstract available.
AMPK activation protects against prostate cancer by inducing a catabolic cellular state.
Penfold L, Woods A, Pollard AE, Arizanova J, Pascual-Navarro E, Muckett PJ, Dore MH, Montoya A, Whilding C, Fets L, Mokochinski J, Constantin TA, Varela-Carver A, Leach DA, Bevan CL, Nikitin AY, Hall Z, Carling D. Penfold L, et al. Cell Rep. 2023 Apr 25;42(4):112396. doi: 10.1016/j.celrep.2023.112396. Epub 2023 Apr 15. Cell Rep. 2023. PMID: 37061917 Free PMC article.
The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer.
Constantin TA, Varela-Carver A, Greenland KK, de Almeida GS, Olden E, Penfold L, Ang S, Ormrod A, Leach DA, Lai CF, Ainscow EK, Bahl AK, Carling D, Fuchter MJ, Ali S, Bevan CL. Constantin TA, et al. Among authors: penfold l. Br J Cancer. 2023 Jun;128(12):2326-2337. doi: 10.1038/s41416-023-02252-8. Epub 2023 Apr 19. Br J Cancer. 2023. PMID: 37076563 Free PMC article.
Correction: The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer.
Constantin TA, Varela-Carver A, Greenland KK, de Almeida GS, Olden E, Penfold L, Ang S, Ormrod A, Leach DA, Lai CF, Ainscow EK, Bahl AK, Carling D, Fuchter MJ, Ali S, Bevan CL. Constantin TA, et al. Among authors: penfold l. Br J Cancer. 2024 Mar;130(5):892. doi: 10.1038/s41416-024-02606-w. Br J Cancer. 2024. PMID: 38355841 Free PMC article. No abstract available.
The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation.
Parzych K, Saavedra-García P, Valbuena GN, Al-Sadah HA, Robinson ME, Penfold L, Kuzeva DM, Ruiz-Tellez A, Loaiza S, Holzmann V, Caputo V, Johnson DC, Kaiser MF, Karadimitris A, Lam EW, Chevet E, Feldhahn N, Keun HC, Auner HW. Parzych K, et al. Among authors: penfold l. Oncogene. 2019 Apr;38(17):3216-3231. doi: 10.1038/s41388-018-0651-z. Epub 2019 Jan 9. Oncogene. 2019. PMID: 30626938 Free PMC article.
Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs.
Saavedra-García P, Roman-Trufero M, Al-Sadah HA, Blighe K, López-Jiménez E, Christoforou M, Penfold L, Capece D, Xiong X, Miao Y, Parzych K, Caputo VS, Siskos AP, Encheva V, Liu Z, Thiel D, Kaiser MF, Piazza P, Chaidos A, Karadimitris A, Franzoso G, Snijders AP, Keun HC, Oyarzún DA, Barahona M, Auner HW. Saavedra-García P, et al. Among authors: penfold l. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2018229118. doi: 10.1073/pnas.2018229118. Proc Natl Acad Sci U S A. 2021. PMID: 33883278 Free PMC article.
Cloning for the Twenty-First Century and Its Place in Endangered Species Conservation.
Cowl VB, Comizzoli P, Appeltant R, Bolton RL, Browne RK, Holt WV, Penfold LM, Swegen A, Walker SL, Williams SA. Cowl VB, et al. Among authors: penfold lm. Annu Rev Anim Biosci. 2024 Feb 15;12:91-112. doi: 10.1146/annurev-animal-071423-093523. Epub 2023 Nov 21. Annu Rev Anim Biosci. 2024. PMID: 37988633 Free article. Review.
66 results