Pellicciari R - Search Results

1

Development of 3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-sulfate sodium salt (INT-767): Process optimization, synthesis and characterization of metabolites.

Cerra B, Venturoni F, Souma M, Ceccarelli G, Lozza AM, Passeri D, De Franco F, Baxendale IR, Pellicciari R, Macchiarulo A, Gioiello A. Cerra B, et al. Among authors: pellicciari r. Eur J Med Chem. 2022 Nov 15;242:114652. doi: 10.1016/j.ejmech.2022.114652. Epub 2022 Aug 20. Eur J Med Chem. 2022. PMID: 36049273

2

Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.

Pellicciari R, Sato H, Gioiello A, Costantino G, Macchiarulo A, Sadeghpour BM, Giorgi G, Schoonjans K, Auwerx J. Pellicciari R, et al. J Med Chem. 2007 Sep 6;50(18):4265-8. doi: 10.1021/jm070633p. Epub 2007 Aug 9. J Med Chem. 2007. PMID: 17685603

3

Extending SAR of bile acids as FXR ligands: discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine.

Gioiello A, Macchiarulo A, Carotti A, Filipponi P, Costantino G, Rizzo G, Adorini L, Pellicciari R. Gioiello A, et al. Among authors: pellicciari r. Bioorg Med Chem. 2011 Apr 15;19(8):2650-8. doi: 10.1016/j.bmc.2011.03.004. Epub 2011 Mar 10. Bioorg Med Chem. 2011. PMID: 21459580

4

Bile acid derivatives as ligands of the farnesoid x receptor: molecular determinants for bile acid binding and receptor modulation.

Gioiello A, Cerra B, Mostarda S, Guercini C, Pellicciari R, Macchiarulo A. Gioiello A, et al. Among authors: pellicciari r. Curr Top Med Chem. 2014;14(19):2159-74. doi: 10.2174/1568026614666141112100208. Curr Top Med Chem. 2014. PMID: 25388535 Review.

5

Beyond bile acids: targeting Farnesoid X Receptor (FXR) with natural and synthetic ligands.

Carotti A, Marinozzi M, Custodi C, Cerra B, Pellicciari R, Gioiello A, Macchiarulo A. Carotti A, et al. Among authors: pellicciari r. Curr Top Med Chem. 2014;14(19):2129-42. doi: 10.2174/1568026614666141112094058. Curr Top Med Chem. 2014. PMID: 25388537 Review.

6

Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders.

Pellicciari R, Passeri D, De Franco F, Mostarda S, Filipponi P, Colliva C, Gadaleta RM, Franco P, Carotti A, Macchiarulo A, Roda A, Moschetta A, Gioiello A. Pellicciari R, et al. J Med Chem. 2016 Oct 13;59(19):9201-9214. doi: 10.1021/acs.jmedchem.6b01126. Epub 2016 Oct 4. J Med Chem. 2016. PMID: 27652492

7

Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification.

Mostarda S, Passeri D, Carotti A, Cerra B, Colliva C, Benicchi T, Macchiarulo A, Pellicciari R, Gioiello A. Mostarda S, et al. Among authors: pellicciari r. Eur J Med Chem. 2018 Jan 20;144:349-358. doi: 10.1016/j.ejmech.2017.12.034. Epub 2017 Dec 11. Eur J Med Chem. 2018. PMID: 29275233

8

Farnesoid X receptor activation by the novel agonist TC-100 (3α, 7α, 11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid) preserves the intestinal barrier integrity and promotes intestinal microbial reshaping in a mouse model of obstructed bile acid flow.

Marzano M, Fosso B, Colliva C, Notario E, Passeri D, Intranuovo M, Gioiello A, Adorini L, Pesole G, Pellicciari R, Moschetta A, Gadaleta RM. Marzano M, et al. Among authors: pellicciari r. Biomed Pharmacother. 2022 Sep;153:113380. doi: 10.1016/j.biopha.2022.113380. Epub 2022 Jul 19. Biomed Pharmacother. 2022. PMID: 36076475 Free article.

9

Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.

Pellicciari R, Costantino G, Camaioni E, Sadeghpour BM, Entrena A, Willson TM, Fiorucci S, Clerici C, Gioiello A. Pellicciari R, et al. J Med Chem. 2004 Aug 26;47(18):4559-69. doi: 10.1021/jm049904b. J Med Chem. 2004. PMID: 15317466

10

Molecular dynamics simulation of the ligand binding domain of farnesoid X receptor. Insights into helix-12 stability and coactivator peptide stabilization in response to agonist binding.

Costantino G, Entrena-Guadix A, Macchiarulo A, Gioiello A, Pellicciari R. Costantino G, et al. Among authors: pellicciari r. J Med Chem. 2005 May 5;48(9):3251-9. doi: 10.1021/jm049182o. J Med Chem. 2005. PMID: 15857131

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