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2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach.
Schehr M , Ianes C , Weisner J , Heintze L , Müller MP , Pichlo C , Charl J , Brunstein E , Ewert J , Lehr M , Baumann U , Rauh D , Knippschild U , Peifer C , Herges R . Schehr M , et al. Among authors: peifer c. Photochem Photobiol Sci. 2019 Jun 12;18(6):1398-1407. doi: 10.1039/c9pp00010k. Photochem Photobiol Sci. 2019. PMID: 30924488
A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε.
Dolde C, Bischof J, Grüter S, Montada A, Halekotte J, Peifer C, Kalbacher H, Baumann U, Knippschild U, Suter B. Dolde C, et al. Among authors: peifer c. J Cell Sci. 2018 Jan 4;131(1):jcs207316. doi: 10.1242/jcs.207316. J Cell Sci. 2018. PMID: 29222110 Free PMC article.
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
García-Reyes B, Witt L, Jansen B, Karasu E, Gehring T, Leban J, Henne-Bruns D, Pichlo C, Brunstein E, Baumann U, Wesseler F, Rathmer B, Schade D, Peifer C, Knippschild U. García-Reyes B, et al. Among authors: peifer c. J Med Chem. 2018 May 10;61(9):4087-4102. doi: 10.1021/acs.jmedchem.8b00095. Epub 2018 May 1. J Med Chem. 2018. PMID: 29630366
Axitinib: A Photoswitchable Approved Tyrosine Kinase Inhibitor.
Schmidt D, Rodat T, Heintze L, Weber J, Horbert R, Girreser U, Raeker T, Bußmann L, Kriegs M, Hartke B, Peifer C. Schmidt D, et al. Among authors: peifer c. ChemMedChem. 2018 Nov 20;13(22):2415-2426. doi: 10.1002/cmdc.201800531. Epub 2018 Nov 5. ChemMedChem. 2018. PMID: 30199151
Kinase activity of casein kinase 1 delta (CK1δ) is modulated by protein kinase C α (PKCα) by site-specific phosphorylation within the kinase domain of CK1δ.
Meng Z, Böhm T, Xu P, Henne-Bruns D, Peifer C, Witt L, Knippschild U, Bischof J. Meng Z, et al. Among authors: peifer c. Biochim Biophys Acta Proteins Proteom. 2019 Jul-Aug;1867(7-8):710-721. doi: 10.1016/j.bbapap.2019.05.004. Epub 2019 May 13. Biochim Biophys Acta Proteins Proteom. 2019. PMID: 31096047
86 results