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BCG∆BCG1419c and BCG differ in induction of autophagy, c-di-GMP content, proteome, and progression of lung pathology in Mycobacterium tuberculosis HN878-infected male BALB/c mice.
Aceves-Sánchez MJ, Barrios-Payán JA, Segura-Cerda CA, Flores-Valdez MA, Mata-Espinosa D, Pedroza-Roldán C, Yadav R, Saini DK, de la Cruz MA, Ares MA, Bielefeldt-Ohmann H, Baay-Guzmán G, Vergne I, Velázquez-Fernández JB, Barba León J, Hernández-Pando R. Aceves-Sánchez MJ, et al. Among authors: pedroza roldan c. Vaccine. 2023 Jun 13;41(26):3824-3835. doi: 10.1016/j.vaccine.2023.04.065. Epub 2023 May 8. Vaccine. 2023. PMID: 37164819
Immune response elicited by two rBCG strains devoid of genes involved in c-di-GMP metabolism affect protection versus challenge with M. tuberculosis strains of different virulence.
Segura-Cerda CA, Aceves-Sánchez MJ, Marquina-Castillo B, Mata-Espinoza D, Barrios-Payán J, Vega-Domínguez PJ, Pedroza-Roldán C, Bravo-Madrigal J, Vallejo-Cardona AA, Hernández-Pando R, Flores-Valdez MA. Segura-Cerda CA, et al. Among authors: pedroza roldan c. Vaccine. 2018 Apr 12;36(16):2069-2078. doi: 10.1016/j.vaccine.2018.03.014. Epub 2018 Mar 15. Vaccine. 2018. PMID: 29550192
The BCGΔBCG1419c Vaccine Candidate Reduces Lung Pathology, IL-6, TNF-α, and IL-10 During Chronic TB Infection.
Flores-Valdez MA, Pedroza-Roldán C, Aceves-Sánchez MJ, Peterson EJR, Baliga NS, Hernández-Pando R, Troudt J, Creissen E, Izzo L, Bielefeldt-Ohmann H, Bickett T, Izzo AA. Flores-Valdez MA, et al. Among authors: pedroza roldan c. Front Microbiol. 2018 Jun 12;9:1281. doi: 10.3389/fmicb.2018.01281. eCollection 2018. Front Microbiol. 2018. PMID: 29946316 Free PMC article.
BCG constitutively expressing the adenylyl cyclase encoded by Rv2212 increases its immunogenicity and reduces replication of M. tuberculosis in lungs of BALB/c mice.
Pedroza-Roldán C, Marquina-Castillo B, Mata-Espinosa D, Barrios-Payán J, Aceves-Sánchez MJ, Hernández Pando R, Flores-Valdez MA. Pedroza-Roldán C, et al. Tuberculosis (Edinb). 2018 Dec;113:19-25. doi: 10.1016/j.tube.2018.08.012. Epub 2018 Aug 24. Tuberculosis (Edinb). 2018. PMID: 30514503
Vaccination with BCGΔBCG1419c protects against pulmonary and extrapulmonary TB and is safer than BCG.
Aceves-Sánchez MJ, Flores-Valdez MA, Pedroza-Roldán C, Creissen E, Izzo L, Silva-Angulo F, Dawson C, Izzo A, Bielefeldt-Ohmann H, Segura-Cerda CA, López-Romero W, Bravo-Madrigal J, Barrios-Payán JA, de la Cruz MÁ, Ares M, Jorge-Espinoza MG. Aceves-Sánchez MJ, et al. Among authors: pedroza roldan c. Sci Rep. 2021 Jun 14;11(1):12417. doi: 10.1038/s41598-021-91993-8. Sci Rep. 2021. PMID: 34127755 Free PMC article.
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