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HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.
Mirtschink P, Krishnan J, Grimm F, Sarre A, Hörl M, Kayikci M, Fankhauser N, Christinat Y, Cortijo C, Feehan O, Vukolic A, Sossalla S, Stehr SN, Ule J, Zamboni N, Pedrazzini T, Krek W. Mirtschink P, et al. Among authors: pedrazzini t. Nature. 2015 Jun 25;522(7557):444-449. doi: 10.1038/nature14508. Epub 2015 Jun 17. Nature. 2015. PMID: 26083752 Free PMC article.
Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.
Krishnan J, Suter M, Windak R, Krebs T, Felley A, Montessuit C, Tokarska-Schlattner M, Aasum E, Bogdanova A, Perriard E, Perriard JC, Larsen T, Pedrazzini T, Krek W. Krishnan J, et al. Among authors: pedrazzini t. Cell Metab. 2009 Jun;9(6):512-24. doi: 10.1016/j.cmet.2009.05.005. Cell Metab. 2009. PMID: 19490906 Free article.
The Notch pathway controls fibrotic and regenerative repair in the adult heart.
Nemir M, Metrich M, Plaisance I, Lepore M, Cruchet S, Berthonneche C, Sarre A, Radtke F, Pedrazzini T. Nemir M, et al. Among authors: pedrazzini t. Eur Heart J. 2014 Aug 21;35(32):2174-85. doi: 10.1093/eurheartj/ehs269. Epub 2012 Nov 19. Eur Heart J. 2014. PMID: 23166366 Free PMC article.
Inhibition of the Hypoxia-Inducible Factor 1α-Induced Cardiospecific HERNA1 Enhance-Templated RNA Protects From Heart Disease.
Mirtschink P, Bischof C, Pham MD, Sharma R, Khadayate S, Rossi G, Fankhauser N, Traub S, Sossalla S, Hagag E, Berthonneche C, Sarre A, Stehr SN, Grote P, Pedrazzini T, Dimmeler S, Krek W, Krishnan J. Mirtschink P, et al. Among authors: pedrazzini t. Circulation. 2019 Jun 11;139(24):2778-2792. doi: 10.1161/CIRCULATIONAHA.118.036769. Epub 2019 Mar 29. Circulation. 2019. PMID: 30922078 Free PMC article.
Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease.
Bischof C, Mirtschink P, Yuan T, Wu M, Zhu C, Kaur J, Pham MD, Gonzalez-Gonoggia S, Hammer M, Rogg EM, Sharma R, Bottermann K, Gercken B, Hagag E, Berthonneche C, Sossalla S, Stehr SN, Maxeiner J, Duda MA, Latreille M, Zamboni N, Martelli F, Pedrazzini T, Dimmeler S, Krishnan J. Bischof C, et al. Among authors: pedrazzini t. Sci Transl Med. 2021 Dec 8;13(623):eabi7964. doi: 10.1126/scitranslmed.abi7964. Epub 2021 Dec 8. Sci Transl Med. 2021. PMID: 34878823
The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury in murine males.
Rogala S, Ali T, Melissari MT, Währisch S, Schuster P, Sarre A, Emídio RC, Boettger T, Rogg EM, Kaur J, Krishnan J, Dumbović G, Dimmeler S, Ounzain S, Pedrazzini T, Herrmann BG, Grote P. Rogala S, et al. Among authors: pedrazzini t. Nat Commun. 2023 Nov 2;14(1):7024. doi: 10.1038/s41467-023-42760-y. Nat Commun. 2023. PMID: 37919291 Free PMC article.
139 results