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The botanical drug PBI-05204, a supercritical CO2 extract of Nerium oleander, sensitizes alveolar and embryonal rhabdomyosarcoma to radiotherapy in vitro and in vivo.
Vaccaro S, Rossetti A, Porrazzo A, Camero S, Cassandri M, Pomella S, Tomaciello M, Macioce G, Pedini F, Barillari G, Marchese C, Rota R, Cenci G, Tombolini M, Newman RA, Yang P, Codenotti S, Fanzani A, Megiorni F, Festuccia C, Minniti G, Gravina GL, Vulcano F, Milazzo L, Marampon F. Vaccaro S, et al. Among authors: pedini f. Front Pharmacol. 2022 Dec 1;13:1071176. doi: 10.3389/fphar.2022.1071176. eCollection 2022. Front Pharmacol. 2022. PMID: 36532747 Free PMC article.
MiR126-targeted-nanoparticles combined with PI3K/AKT inhibitor as a new strategy to overcome melanoma resistance.
Arasi MB, De Luca G, Chronopoulou L, Pedini F, Petrucci E, Flego M, Stringaro A, Colone M, Pasquini L, Spada M, Lulli V, Perrotta MC, Calin GA, Palocci C, Biffoni M, Felicetti F, Felli N. Arasi MB, et al. Among authors: pedini f. Mol Ther. 2024 Jan 3;32(1):152-167. doi: 10.1016/j.ymthe.2023.11.021. Epub 2023 Nov 21. Mol Ther. 2024. PMID: 37990493 Free article.
Extracellular vesicles produced by irradiated endothelial or Glioblastoma stem cells promote tumor growth and vascularization modulating tumor microenvironment.
Castellani G, Buccarelli M, D'Alessandris QG, Ilari R, Cappannini A, Pedini F, Boe A, Lulli V, Parolini I, Giannetti S, Biffoni M, Zappavigna V, Marziali G, Pallini R, Ricci-Vitiani L. Castellani G, et al. Among authors: pedini f. Cancer Cell Int. 2024 Feb 12;24(1):72. doi: 10.1186/s12935-024-03253-0. Cancer Cell Int. 2024. PMID: 38347567 Free PMC article.
The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity.
Siciliano G, Di Paolo V, Rotili D, Migale R, Pedini F, Casella M, Camerini S, Dalzoppo D, Henderson R, Huijs T, Dechering KJ, Mai A, Caccuri AM, Lalle M, Quintieri L, Alano P. Siciliano G, et al. Among authors: pedini f. Pharmaceuticals (Basel). 2022 Jan 29;15(2):168. doi: 10.3390/ph15020168. Pharmaceuticals (Basel). 2022. PMID: 35215282 Free PMC article.
Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth.
Buccarelli M, D'Alessandris QG, Matarrese P, Mollinari C, Signore M, Cappannini A, Martini M, D'Aliberti P, De Luca G, Pedini F, Boe A, Biffoni M, Pallini R, Ricci-Vitiani L. Buccarelli M, et al. Among authors: pedini f. J Exp Clin Cancer Res. 2021 Jul 12;40(1):228. doi: 10.1186/s13046-021-02031-4. J Exp Clin Cancer Res. 2021. PMID: 34253243 Free PMC article.
Joint action of miR-126 and MAPK/PI3K inhibitors against metastatic melanoma.
Pedini F, De Luca G, Felicetti F, Puglisi R, Boe A, Arasi MB, Fratini F, Mattia G, Spada M, Caporali S, Biffoni M, Giuliani A, Carè A, Felli N. Pedini F, et al. Mol Oncol. 2019 Sep;13(9):1836-1854. doi: 10.1002/1878-0261.12506. Epub 2019 Aug 6. Mol Oncol. 2019. PMID: 31115969 Free PMC article.
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