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Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration.
Nat Commun. 2022 Sep 21;13(1):5308. doi: 10.1038/s41467-022-32944-3.
Nat Commun. 2022.
PMID: 36130946
Free PMC article.
Clinical Trial.
Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
Pensalfini A, Kim S, Subbanna S, Bleiwas C, Goulbourne CN, Stavrides PH, Jiang Y, Lee JH, Darji S, Pawlik M, Huo C, Peddy J, Berg MJ, Smiley JF, Basavarajappa BS, Nixon RA.
Pensalfini A, et al. Among authors: peddy j.
Cell Rep. 2020 Nov 24;33(8):108420. doi: 10.1016/j.celrep.2020.108420.
Cell Rep. 2020.
PMID: 33238112
Free PMC article.
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Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques.
Lee JH, Yang DS, Goulbourne CN, Im E, Stavrides P, Pensalfini A, Chan H, Bouchet-Marquis C, Bleiwas C, Berg MJ, Huo C, Peddy J, Pawlik M, Levy E, Rao M, Staufenbiel M, Nixon RA.
Lee JH, et al. Among authors: peddy j.
Nat Neurosci. 2022 Jun;25(6):688-701. doi: 10.1038/s41593-022-01084-8. Epub 2022 Jun 2.
Nat Neurosci. 2022.
PMID: 35654956
Free PMC article.
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Autophagy is a novel pathway for neurofilament protein degradation in vivo.
Rao MV, Darji S, Stavrides PH, Goulbourne CN, Kumar A, Yang DS, Yoo L, Peddy J, Lee JH, Yuan A, Nixon RA.
Rao MV, et al. Among authors: peddy j.
Autophagy. 2023 Apr;19(4):1277-1292. doi: 10.1080/15548627.2022.2124500. Epub 2022 Sep 21.
Autophagy. 2023.
PMID: 36131358
Free PMC article.
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