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2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.
Wu SY, Yang X, Gharpure KM, Hatakeyama H, Egli M, McGuire MH, Nagaraja AS, Miyake TM, Rupaimoole R, Pecot CV, Taylor M, Pradeep S, Sierant M, Rodriguez-Aguayo C, Choi HJ, Previs RA, Armaiz-Pena GN, Huang L, Martinez C, Hassell T, Ivan C, Sehgal V, Singhania R, Han HD, Su C, Kim JH, Dalton HJ, Kovvali C, Keyomarsi K, McMillan NA, Overwijk WW, Liu J, Lee JS, Baggerly KA, Lopez-Berestein G, Ram PT, Nawrot B, Sood AK. Wu SY, et al. Among authors: pecot cv. Nat Commun. 2014 Mar 12;5:3459. doi: 10.1038/ncomms4459. Nat Commun. 2014. PMID: 24619206 Free PMC article.
Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.
Rupaimoole R, Wu SY, Pradeep S, Ivan C, Pecot CV, Gharpure KM, Nagaraja AS, Armaiz-Pena GN, McGuire M, Zand B, Dalton HJ, Filant J, Miller JB, Lu C, Sadaoui NC, Mangala LS, Taylor M, van den Beucken T, Koch E, Rodriguez-Aguayo C, Huang L, Bar-Eli M, Wouters BG, Radovich M, Ivan M, Calin GA, Zhang W, Lopez-Berestein G, Sood AK. Rupaimoole R, et al. Among authors: pecot cv. Nat Commun. 2014 Oct 29;5:5202. doi: 10.1038/ncomms6202. Nat Commun. 2014. PMID: 25351346 Free PMC article.
A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer.
Wu SY, Rupaimoole R, Shen F, Pradeep S, Pecot CV, Ivan C, Nagaraja AS, Gharpure KM, Pham E, Hatakeyama H, McGuire MH, Haemmerle M, Vidal-Anaya V, Olsen C, Rodriguez-Aguayo C, Filant J, Ehsanipour EA, Herbrich SM, Maiti SN, Huang L, Kim JH, Zhang X, Han HD, Armaiz-Pena GN, Seviour EG, Tucker S, Zhang M, Yang D, Cooper LJ, Ali-Fehmi R, Bar-Eli M, Lee JS, Ram PT, Baggerly KA, Lopez-Berestein G, Hung MC, Sood AK. Wu SY, et al. Among authors: pecot cv. Nat Commun. 2016 Apr 4;7:11169. doi: 10.1038/ncomms11169. Nat Commun. 2016. PMID: 27041221 Free PMC article.
Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking.
Porrello A, Leslie PL, Harrison EB, Gorentla BK, Kattula S, Ghosh SK, Azam SH, Holtzhausen A, Chao YL, Hayward MC, Waugh TA, Bae S, Godfrey V, Randell SH, Oderup C, Makowski L, Weiss J, Wilkerson MD, Hayes DN, Earp HS, Baldwin AS, Wolberg AS, Pecot CV. Porrello A, et al. Among authors: pecot cv. Nat Commun. 2018 May 18;9(1):1988. doi: 10.1038/s41467-018-04355-w. Nat Commun. 2018. PMID: 29777108 Free PMC article.
Phase II study of stereotactic radiosurgery for the treatment of patients with oligoprogression on erlotinib.
Weiss J, Kavanagh B, Deal A, Villaruz L, Stevenson J, Camidge R, Borghaei H, West J, Kirpalani P, Morris D, Lee C, Pecot CV, Zagar T, Stinchcombe T, Pennell N. Weiss J, et al. Among authors: pecot cv. Cancer Treat Res Commun. 2019;19:100126. doi: 10.1016/j.ctarc.2019.100126. Epub 2019 Feb 26. Cancer Treat Res Commun. 2019. PMID: 30852467 Clinical Trial.
Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β-induced Serpine1.
McCann JV, Xiao L, Kim DJ, Khan OF, Kowalski PS, Anderson DG, Pecot CV, Azam SH, Parker JS, Tsai YS, Wolberg AS, Turner SD, Tatsumi K, Mackman N, Dudley AC. McCann JV, et al. Among authors: pecot cv. J Clin Invest. 2019 Mar 11;129(4):1654-1670. doi: 10.1172/JCI123106. eCollection 2019 Mar 11. J Clin Invest. 2019. PMID: 30855280 Free PMC article.
Quaking orchestrates a post-transcriptional regulatory network of endothelial cell cycle progression critical to angiogenesis and metastasis.
Azam SH, Porrello A, Harrison EB, Leslie PL, Liu X, Waugh TA, Belanger A, Mangala LS, Lopez-Berestein G, Wilson HL, McCann JV, Kim WY, Sood AK, Liu J, Dudley AC, Pecot CV. Azam SH, et al. Among authors: pecot cv. Oncogene. 2019 Jun;38(26):5191-5210. doi: 10.1038/s41388-019-0786-6. Epub 2019 Mar 27. Oncogene. 2019. PMID: 30918328 Free PMC article.
73 results