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Design, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases.
RSC Med Chem. 2024 Feb 20;15(3):963-980. doi: 10.1039/d3md00708a. eCollection 2024 Mar 20.
RSC Med Chem. 2024.
PMID: 38516603
Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core.
Ţînţaş ML, Peauger L, Alix F, Papamicaël C, Besson T, Sopková-de Oliveira Santos J, Gembus V, Levacher V.
Ţînţaş ML, et al. Among authors: peauger l.
Molecules. 2022 Dec 21;28(1):36. doi: 10.3390/molecules28010036.
Molecules. 2022.
PMID: 36615235
Free PMC article.
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Access to Highly Enantioenriched Donepezil-like 1,4-Dihydropyridines as Promising Anti-Alzheimer Prodrug Candidates via Enantioselective Tsuji Allylation and Organocatalytic Aza-Ene-Type Domino Reactions.
Ţînţaş ML, Azzouz R, Peauger L, Gembus V, Petit E, Bailly L, Papamicaël C, Levacher V.
Ţînţaş ML, et al. Among authors: peauger l.
J Org Chem. 2018 Sep 7;83(17):10231-10240. doi: 10.1021/acs.joc.8b01442. Epub 2018 Jul 24.
J Org Chem. 2018.
PMID: 30004228
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Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship.
Azzouz R, Peauger L, Gembus V, Ţînţaş ML, Sopková-de Oliveira Santos J, Papamicaël C, Levacher V.
Azzouz R, et al. Among authors: peauger l.
Eur J Med Chem. 2018 Feb 10;145:165-190. doi: 10.1016/j.ejmech.2017.12.084. Epub 2017 Dec 27.
Eur J Med Chem. 2018.
PMID: 29324339
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Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a "Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation.
Peauger L, Azzouz R, Gembus V, Ţînţaş ML, Sopková-de Oliveira Santos J, Bohn P, Papamicaël C, Levacher V.
Peauger L, et al.
J Med Chem. 2017 Jul 13;60(13):5909-5926. doi: 10.1021/acs.jmedchem.7b00702. Epub 2017 Jun 29.
J Med Chem. 2017.
PMID: 28613859
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