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Design, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases.
Ţînţaş ML, Peauger L, Barré A, Papamicaël C, Besson T, Sopkovà-de Oliveira Santos J, Gembus V, Levacher V. Ţînţaş ML, et al. Among authors: peauger l. RSC Med Chem. 2024 Feb 20;15(3):963-980. doi: 10.1039/d3md00708a. eCollection 2024 Mar 20. RSC Med Chem. 2024. PMID: 38516603
Access to Highly Enantioenriched Donepezil-like 1,4-Dihydropyridines as Promising Anti-Alzheimer Prodrug Candidates via Enantioselective Tsuji Allylation and Organocatalytic Aza-Ene-Type Domino Reactions.
Ţînţaş ML, Azzouz R, Peauger L, Gembus V, Petit E, Bailly L, Papamicaël C, Levacher V. Ţînţaş ML, et al. Among authors: peauger l. J Org Chem. 2018 Sep 7;83(17):10231-10240. doi: 10.1021/acs.joc.8b01442. Epub 2018 Jul 24. J Org Chem. 2018. PMID: 30004228
Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship.
Azzouz R, Peauger L, Gembus V, Ţînţaş ML, Sopková-de Oliveira Santos J, Papamicaël C, Levacher V. Azzouz R, et al. Among authors: peauger l. Eur J Med Chem. 2018 Feb 10;145:165-190. doi: 10.1016/j.ejmech.2017.12.084. Epub 2017 Dec 27. Eur J Med Chem. 2018. PMID: 29324339