Pearson PG - Search Results

1

Mechanistic studies on metabolic interactions between gemfibrozil and statins.

Prueksaritanont T, Zhao JJ, Ma B, Roadcap BA, Tang C, Qiu Y, Liu L, Lin JH, Pearson PG, Baillie TA. Prueksaritanont T, et al. Among authors: pearson pg. J Pharmacol Exp Ther. 2002 Jun;301(3):1042-51. doi: 10.1124/jpet.301.3.1042. J Pharmacol Exp Ther. 2002. PMID: 12023536

2

Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization.

Prueksaritanont T, Subramanian R, Fang X, Ma B, Qiu Y, Lin JH, Pearson PG, Baillie TA. Prueksaritanont T, et al. Among authors: pearson pg. Drug Metab Dispos. 2002 May;30(5):505-12. doi: 10.1124/dmd.30.5.505. Drug Metab Dispos. 2002. PMID: 11950779

3

Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein.

Kumar S, Kwei GY, Poon GK, Iliff SA, Wang Y, Chen Q, Franklin RB, Didolkar V, Wang RW, Yamazaki M, Chiu SH, Lin JH, Pearson PG, Baillie TA. Kumar S, et al. Among authors: pearson pg. J Pharmacol Exp Ther. 2003 Mar;304(3):1161-71. doi: 10.1124/jpet.102.045096. J Pharmacol Exp Ther. 2003. PMID: 12604693

4

Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins.

Singh R, Silva Elipe MV, Pearson PG, Arison BH, Wong BK, White R, Yu X, Burgey CS, Lin JH, Baillie TA. Singh R, et al. Among authors: pearson pg. Chem Res Toxicol. 2003 Feb;16(2):198-207. doi: 10.1021/tx025635l. Chem Res Toxicol. 2003. PMID: 12588191

5

Evaluation of microdosing strategies for studies in preclinical drug development: demonstration of linear pharmacokinetics in dogs of a nucleoside analog over a 50-fold dose range.

Sandhu P, Vogel JS, Rose MJ, Ubick EA, Brunner JE, Wallace MA, Adelsberger JK, Baker MP, Henderson PT, Pearson PG, Baillie TA. Sandhu P, et al. Among authors: pearson pg. Drug Metab Dispos. 2004 Nov;32(11):1254-9. doi: 10.1124/dmd.104.000422. Epub 2004 Jul 30. Drug Metab Dispos. 2004. PMID: 15286054

6

Enzyme kinetics of cytochrome P450-mediated reactions.

Shou M, Lin Y, Lu P, Tang C, Mei Q, Cui D, Tang W, Ngui JS, Lin CC, Singh R, Wong BK, Yergey JA, Lin JH, Pearson PG, Baillie TA, Rodrigues AD, Rushmore TH. Shou M, et al. Among authors: pearson pg. Curr Drug Metab. 2001 Mar;2(1):17-36. doi: 10.2174/1389200013338784. Curr Drug Metab. 2001. PMID: 11465149 Review.

7

Study of the fragmentation mechanism of protonated 6-hydroxychlorzoxazone: application in simultaneous analysis of CYP2E1 activity with major human cytochrome P450s.

Anari MR, Bakhtiar R, Franklin RB, Pearson PG, Baillie TA. Anari MR, et al. Among authors: pearson pg. Anal Chem. 2003 Feb 1;75(3):469-78. doi: 10.1021/ac026157m. Anal Chem. 2003. PMID: 12585472

8

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

Kassahun K, Pearson PG, Tang W, McIntosh I, Leung K, Elmore C, Dean D, Wang R, Doss G, Baillie TA. Kassahun K, et al. Among authors: pearson pg. Chem Res Toxicol. 2001 Jan;14(1):62-70. doi: 10.1021/tx000180q. Chem Res Toxicol. 2001. PMID: 11170509

9

Metabolism of N-methylformamide in mice: primary kinetic deuterium isotope effect and identification of S-(N-methylcarbamoyl)glutathione as a metabolite.

Threadgill MD, Axworthy DB, Baillie TA, Farmer PB, Farrow KC, Gescher A, Kestell P, Pearson PG, Shaw AJ. Threadgill MD, et al. Among authors: pearson pg. J Pharmacol Exp Ther. 1987 Jul;242(1):312-9. J Pharmacol Exp Ther. 1987. PMID: 3612534

10

Metabolites of caspofungin acetate, a potent antifungal agent, in human plasma and urine.

Balani SK, Xu X, Arison BH, Silva MV, Gries A, DeLuna FA, Cui D, Kari PH, Ly T, Hop CE, Singh R, Wallace MA, Dean DC, Lin JH, Pearson PG, Baillie TA. Balani SK, et al. Among authors: pearson pg. Drug Metab Dispos. 2000 Nov;28(11):1274-8. Drug Metab Dispos. 2000. PMID: 11038152

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