Pearson AR - Search Results

1

Isolation of an asymmetric RNA uncoating intermediate for a single-stranded RNA plant virus.

Bakker SE, Ford RJ, Barker AM, Robottom J, Saunders K, Pearson AR, Ranson NA, Stockley PG. Bakker SE, et al. Among authors: pearson ar. J Mol Biol. 2012 Mar 16;417(1-2):65-78. doi: 10.1016/j.jmb.2012.01.017. Epub 2012 Jan 27. J Mol Biol. 2012. PMID: 22306464 Free PMC article.

2

Structural insights into substrate specificity in variants of N-acetylneuraminic Acid lyase produced by directed evolution.

Campeotto I, Bolt AH, Harman TA, Dennis C, Trinh CH, Phillips SE, Nelson A, Pearson AR, Berry A. Campeotto I, et al. Among authors: pearson ar. J Mol Biol. 2010 Nov 19;404(1):56-69. doi: 10.1016/j.jmb.2010.08.008. Epub 2010 Sep 6. J Mol Biol. 2010. PMID: 20826162 Free PMC article.

3

Sequence-specific, RNA-protein interactions overcome electrostatic barriers preventing assembly of satellite tobacco necrosis virus coat protein.

Ford RJ, Barker AM, Bakker SE, Coutts RH, Ranson NA, Phillips SE, Pearson AR, Stockley PG. Ford RJ, et al. Among authors: pearson ar. J Mol Biol. 2013 Mar 25;425(6):1050-64. doi: 10.1016/j.jmb.2013.01.004. Epub 2013 Jan 11. J Mol Biol. 2013. PMID: 23318955 Free PMC article.

4

Packaging signals in single-stranded RNA viruses: nature's alternative to a purely electrostatic assembly mechanism.

Stockley PG, Twarock R, Bakker SE, Barker AM, Borodavka A, Dykeman E, Ford RJ, Pearson AR, Phillips SE, Ranson NA, Tuma R. Stockley PG, et al. Among authors: pearson ar. J Biol Phys. 2013 Mar;39(2):277-87. doi: 10.1007/s10867-013-9313-0. Epub 2013 Apr 12. J Biol Phys. 2013. PMID: 23704797 Free PMC article.

5

Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release.

Foster TL, Thompson GS, Kalverda AP, Kankanala J, Bentham M, Wetherill LF, Thompson J, Barker AM, Clarke D, Noerenberg M, Pearson AR, Rowlands DJ, Homans SW, Harris M, Foster R, Griffin S. Foster TL, et al. Among authors: pearson ar. Hepatology. 2014 Feb;59(2):408-22. doi: 10.1002/hep.26685. Epub 2013 Dec 24. Hepatology. 2014. PMID: 24022996 Free PMC article.

6

Limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle.

Bakker SE, Groppelli E, Pearson AR, Stockley PG, Rowlands DJ, Ranson NA. Bakker SE, et al. Among authors: pearson ar. J Virol. 2014 Jun;88(11):6093-9. doi: 10.1128/JVI.01979-13. Epub 2014 Mar 19. J Virol. 2014. PMID: 24648455 Free PMC article.

7

All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding.

Foster TL, Belyaeva T, Stonehouse NJ, Pearson AR, Harris M. Foster TL, et al. Among authors: pearson ar. J Virol. 2010 Sep;84(18):9267-77. doi: 10.1128/JVI.00616-10. Epub 2010 Jun 30. J Virol. 2010. PMID: 20592076 Free PMC article.

8

Structural insights into the recovery of aldolase activity in N-acetylneuraminic acid lyase by replacement of the catalytically active lysine with γ-thialysine by using a chemical mutagenesis strategy.

Timms N, Windle CL, Polyakova A, Ault JR, Trinh CH, Pearson AR, Nelson A, Berry A. Timms N, et al. Among authors: pearson ar. Chembiochem. 2013 Mar 4;14(4):474-81. doi: 10.1002/cbic.201200714. Epub 2013 Feb 18. Chembiochem. 2013. PMID: 23418011 Free PMC article.

9

Reaction mechanism of N-acetylneuraminic acid lyase revealed by a combination of crystallography, QM/MM simulation, and mutagenesis.

Daniels AD, Campeotto I, van der Kamp MW, Bolt AH, Trinh CH, Phillips SE, Pearson AR, Nelson A, Mulholland AJ, Berry A. Daniels AD, et al. Among authors: pearson ar. ACS Chem Biol. 2014 Apr 18;9(4):1025-32. doi: 10.1021/cb500067z. Epub 2014 Feb 21. ACS Chem Biol. 2014. PMID: 24521460 Free PMC article.

10

The structure of the PanD/PanZ protein complex reveals negative feedback regulation of pantothenate biosynthesis by coenzyme A.

Monteiro DCF, Patel V, Bartlett CP, Nozaki S, Grant TD, Gowdy JA, Thompson GS, Kalverda AP, Snell EH, Niki H, Pearson AR, Webb ME. Monteiro DCF, et al. Among authors: pearson ar. Chem Biol. 2015 Apr 23;22(4):492-503. doi: 10.1016/j.chembiol.2015.03.017. Chem Biol. 2015. PMID: 25910242 Free PMC article.

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