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Page 1
Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function.
Edwards-Hicks J, Apostolova P, Buescher JM, Maib H, Stanczak MA, Corrado M, Klein Geltink RI, Maccari ME, Villa M, Carrizo GE, Sanin DE, Baixauli F, Kelly B, Curtis JD, Haessler F, Patterson A, Field CS, Caputa G, Kyle RL, Soballa M, Cha M, Paul H, Martin J, Grzes KM, Flachsmann L, Mitterer M, Zhao L, Winkler F, Rafei-Shamsabadi DA, Meiss F, Bengsch B, Zeiser R, Puleston DJ, O'Sullivan D, Pearce EJ, Pearce EL. Edwards-Hicks J, et al. Among authors: pearce ej, pearce el. Nat Immunol. 2023 Mar;24(3):516-530. doi: 10.1038/s41590-023-01419-y. Epub 2023 Feb 2. Nat Immunol. 2023. PMID: 36732424 Free PMC article.
Posttranscriptional control of T cell effector function by aerobic glycolysis.
Chang CH, Curtis JD, Maggi LB Jr, Faubert B, Villarino AV, O'Sullivan D, Huang SC, van der Windt GJ, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL. Chang CH, et al. Among authors: pearce ej, pearce el. Cell. 2013 Jun 6;153(6):1239-51. doi: 10.1016/j.cell.2013.05.016. Cell. 2013. PMID: 23746840 Free PMC article.
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability.
van der Windt GJ, O'Sullivan D, Everts B, Huang SC, Buck MD, Curtis JD, Chang CH, Smith AM, Ai T, Faubert B, Jones RG, Pearce EJ, Pearce EL. van der Windt GJ, et al. Among authors: pearce ej, pearce el. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14336-41. doi: 10.1073/pnas.1221740110. Epub 2013 Aug 12. Proc Natl Acad Sci U S A. 2013. PMID: 23940348 Free PMC article.
TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.
Everts B, Amiel E, Huang SC, Smith AM, Chang CH, Lam WY, Redmann V, Freitas TC, Blagih J, van der Windt GJ, Artyomov MN, Jones RG, Pearce EL, Pearce EJ. Everts B, et al. Among authors: pearce ej, pearce el. Nat Immunol. 2014 Apr;15(4):323-32. doi: 10.1038/ni.2833. Epub 2014 Feb 23. Nat Immunol. 2014. PMID: 24562310 Free PMC article.
Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.
O'Sullivan D, van der Windt GJ, Huang SC, Curtis JD, Chang CH, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL. O'Sullivan D, et al. Among authors: pearce ej, pearce el. Immunity. 2014 Jul 17;41(1):75-88. doi: 10.1016/j.immuni.2014.06.005. Epub 2014 Jul 4. Immunity. 2014. PMID: 25001241 Free PMC article.
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.
Huang SC, Everts B, Ivanova Y, O'Sullivan D, Nascimento M, Smith AM, Beatty W, Love-Gregory L, Lam WY, O'Neill CM, Yan C, Du H, Abumrad NA, Urban JF Jr, Artyomov MN, Pearce EL, Pearce EJ. Huang SC, et al. Among authors: pearce ej, pearce el. Nat Immunol. 2014 Sep;15(9):846-55. doi: 10.1038/ni.2956. Epub 2014 Aug 3. Nat Immunol. 2014. PMID: 25086775 Free PMC article.
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