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Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein Using mRNA Display.
Norman A, Franck C, Christie M, Hawkins PME, Patel K, Ashhurst AS, Aggarwal A, Low JKK, Siddiquee R, Ashley CL, Steain M, Triccas JA, Turville S, Mackay JP, Passioura T, Payne RJ. Norman A, et al. Among authors: payne rj. ACS Cent Sci. 2021 Jun 23;7(6):1001-1008. doi: 10.1021/acscentsci.0c01708. Epub 2021 May 27. ACS Cent Sci. 2021. PMID: 34230894 Free PMC article.
A pain-causing and paralytic ant venom glycopeptide.
Robinson SD, Kambanis L, Clayton D, Hinneburg H, Corcilius L, Mueller A, Walker AA, Keramidas A, Kulkarni SS, Jones A, Vetter I, Thaysen-Andersen M, Payne RJ, King GF, Undheim EAB. Robinson SD, et al. Among authors: payne rj. iScience. 2021 Sep 25;24(10):103175. doi: 10.1016/j.isci.2021.103175. eCollection 2021 Oct 22. iScience. 2021. PMID: 34693225 Free PMC article.
Expressed Protein Selenoester Ligation.
Kulkarni SS, Watson EE, Maxwell JWC, Niederacher G, Johansen-Leete J, Huhmann S, Mukherjee S, Norman AR, Kriegesmann J, Becker CFW, Payne RJ. Kulkarni SS, et al. Among authors: payne rj. Angew Chem Int Ed Engl. 2022 May 9;61(20):e202200163. doi: 10.1002/anie.202200163. Epub 2022 Mar 9. Angew Chem Int Ed Engl. 2022. PMID: 35194928 Free PMC article.
A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein.
Thijssen V, Hurdiss DL, Debski-Antoniak OJ, Spence MA, Franck C, Norman A, Aggarwal A, Mokiem NJ, van Dongen DAA, Vermeir SW, Liu M, Li W, Chatziandreou M, Donselaar T, Du W, Drulyte I, Bosch BJ, Snijder J, Turville SG, Payne RJ, Jackson CJ, van Kuppeveld FJM, Jongkees SAK. Thijssen V, et al. Among authors: payne rj. Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2303292120. doi: 10.1073/pnas.2303292120. Epub 2023 Jun 20. Proc Natl Acad Sci U S A. 2023. PMID: 37339194 Free PMC article.
Expressed Protein Selenoester Ligation.
Kulkarni SS, Watson EE, Maxwell JWC, Niederacher G, Johansen-Leete J, Huhmann S, Mukherjee S, Norman AR, Kriegesmann J, Becker CFW, Payne RJ. Kulkarni SS, et al. Among authors: payne rj. Angew Chem Weinheim Bergstr Ger. 2022 May 9;134(20):e202200163. doi: 10.1002/ange.202200163. Epub 2022 Mar 9. Angew Chem Weinheim Bergstr Ger. 2022. PMID: 38505698 Free PMC article.
Cyclic peptides can engage a single binding pocket through highly divergent modes.
Patel K, Walport LJ, Walshe JL, Solomon PD, Low JKK, Tran DH, Mouradian KS, Silva APG, Wilkinson-White L, Norman A, Franck C, Matthews JM, Guss JM, Payne RJ, Passioura T, Suga H, Mackay JP. Patel K, et al. Among authors: payne rj. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26728-26738. doi: 10.1073/pnas.2003086117. Epub 2020 Oct 12. Proc Natl Acad Sci U S A. 2020. PMID: 33046654 Free PMC article.
380 results