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R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm.
Shide K, Kameda T, Markovtsov V, Shimoda HK, Tonkin E, Fang S, Liu C, Gelman M, Lang W, Romero J, McLaughlin J, Bhamidipati S, Clough J, Low C, Reitsma A, Siu S, Pine P, Park G, Torneros A, Duan M, Singh R, Payan DG, Matsunaga T, Hitoshi Y, Shimoda K. Shide K, et al. Among authors: payan dg. Blood. 2011 Jun 23;117(25):6866-75. doi: 10.1182/blood-2010-01-262535. Epub 2011 Apr 29. Blood. 2011. PMID: 21531978 Free article.
R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer.
Holland SJ, Pan A, Franci C, Hu Y, Chang B, Li W, Duan M, Torneros A, Yu J, Heckrodt TJ, Zhang J, Ding P, Apatira A, Chua J, Brandt R, Pine P, Goff D, Singh R, Payan DG, Hitoshi Y. Holland SJ, et al. Among authors: payan dg. Cancer Res. 2010 Feb 15;70(4):1544-54. doi: 10.1158/0008-5472.CAN-09-2997. Epub 2010 Feb 9. Cancer Res. 2010. PMID: 20145120
Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen.
McLaughlin J, Markovtsov V, Li H, Wong S, Gelman M, Zhu Y, Franci C, Lang D, Pali E, Lasaga J, Low C, Zhao F, Chang B, Gururaja TL, Xu W, Baluom M, Sweeny D, Carroll D, Sran A, Thota S, Parmer M, Romane A, Clemens G, Grossbard E, Qu K, Jenkins Y, Kinoshita T, Taylor V, Holland SJ, Argade A, Singh R, Pine P, Payan DG, Hitoshi Y. McLaughlin J, et al. Among authors: payan dg. J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113. doi: 10.1007/s00432-009-0641-1. J Cancer Res Clin Oncol. 2010. PMID: 19609559
Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways.
Jenkins Y, Sun TQ, Li Y, Markovtsov V, Uy G, Gross L, Goff DA, Shaw SJ, Boralsky L, Singh R, Payan DG, Hitoshi Y. Jenkins Y, et al. Among authors: payan dg. BMC Res Notes. 2014 Sep 25;7:674. doi: 10.1186/1756-0500-7-674. BMC Res Notes. 2014. PMID: 25252968 Free PMC article.
Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice.
Baltgalvis KA, White K, Li W, Claypool MD, Lang W, Alcantara R, Singh BK, Friera AM, McLaughlin J, Hansen D, McCaughey K, Nguyen H, Smith IJ, Godinez G, Shaw SJ, Goff D, Singh R, Markovtsov V, Sun TQ, Jenkins Y, Uy G, Li Y, Pan A, Gururaja T, Lau D, Park G, Hitoshi Y, Payan DG, Kinsella TM. Baltgalvis KA, et al. Among authors: payan dg. Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1128-45. doi: 10.1152/ajpheart.00839.2013. Epub 2014 Feb 21. Am J Physiol Heart Circ Physiol. 2014. PMID: 24561866 Free PMC article.
Application of cultured human mast cells (CHMC) for the design and structure-activity relationship of IgE-mediated mast cell activation inhibitors.
Argade A, Bhamidipati S, Li H, Carroll D, Clough J, Keim H, Sylvain C, Rossi AB, Coquilla C, Issakani SD, Masuda ES, Payan DG, Singh R. Argade A, et al. Among authors: payan dg. Bioorg Med Chem Lett. 2015;25(10):2117-21. doi: 10.1016/j.bmcl.2015.03.075. Epub 2015 Mar 31. Bioorg Med Chem Lett. 2015. PMID: 25872982
181 results