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mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.
Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N. Morita M, et al. Among authors: pause a. Cell Metab. 2013 Nov 5;18(5):698-711. doi: 10.1016/j.cmet.2013.10.001. Cell Metab. 2013. PMID: 24206664 Free article.
Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.
Vincent EE, Sergushichev A, Griss T, Gingras MC, Samborska B, Ntimbane T, Coelho PP, Blagih J, Raissi TC, Choinière L, Bridon G, Loginicheva E, Flynn BR, Thomas EC, Tavaré JM, Avizonis D, Pause A, Elder DJ, Artyomov MN, Jones RG. Vincent EE, et al. Among authors: pause a. Mol Cell. 2015 Oct 15;60(2):195-207. doi: 10.1016/j.molcel.2015.08.013. Mol Cell. 2015. PMID: 26474064 Free article.
Folliculin regulates ampk-dependent autophagy and metabolic stress survival.
Possik E, Jalali Z, Nouët Y, Yan M, Gingras MC, Schmeisser K, Panaite L, Dupuy F, Kharitidi D, Chotard L, Jones RG, Hall DH, Pause A. Possik E, et al. Among authors: pause a. PLoS Genet. 2014 Apr 24;10(4):e1004273. doi: 10.1371/journal.pgen.1004273. eCollection 2014 Apr. PLoS Genet. 2014. PMID: 24763318 Free PMC article.
The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation.
Yan M, Gingras MC, Dunlop EA, Nouët Y, Dupuy F, Jalali Z, Possik E, Coull BJ, Kharitidi D, Dydensborg AB, Faubert B, Kamps M, Sabourin S, Preston RS, Davies DM, Roughead T, Chotard L, van Steensel MA, Jones R, Tee AR, Pause A. Yan M, et al. Among authors: pause a. J Clin Invest. 2014 Jun;124(6):2640-50. doi: 10.1172/JCI71749. Epub 2014 Apr 24. J Clin Invest. 2014. PMID: 24762438 Free PMC article.
The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting.
Hall DT, Griss T, Ma JF, Sanchez BJ, Sadek J, Tremblay AMK, Mubaid S, Omer A, Ford RJ, Bedard N, Pause A, Wing SS, Di Marco S, Steinberg GR, Jones RG, Gallouzi IE. Hall DT, et al. Among authors: pause a. EMBO Mol Med. 2018 Jul;10(7):e8307. doi: 10.15252/emmm.201708307. EMBO Mol Med. 2018. PMID: 29844217 Free PMC article.
Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.
Manteghi S, Gingras MC, Kharitidi D, Galarneau L, Marques M, Yan M, Cencic R, Robert F, Paquet M, Witcher M, Pelletier J, Pause A. Manteghi S, et al. Among authors: pause a. Cell Rep. 2016 May 31;15(9):1893-900. doi: 10.1016/j.celrep.2016.04.076. Epub 2016 May 19. Cell Rep. 2016. PMID: 27210750 Free article.
88 results