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2012 1
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Page 1
Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines.
Grychowska K, Olejarz-Maciej A, Blicharz K, Pietruś W, Karcz T, Kurczab R, Koczurkiewicz P, Doroz-Płonka A, Latacz G, Keeri AR, Piska K, Satała G, Pęgiel J, Trybała W, Jastrzębska-Więsek M, Bojarski AJ, Lamaty F, Partyka A, Walczak M, Krawczyk M, Malikowska-Racia N, Popik P, Zajdel P. Grychowska K, et al. Among authors: koczurkiewicz p. Eur J Med Chem. 2022 Jun 5;236:114329. doi: 10.1016/j.ejmech.2022.114329. Epub 2022 Mar 29. Eur J Med Chem. 2022. PMID: 35397400 Free article.
A dual-acting 5-HT6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties.
Canale V, Grychowska K, Kurczab R, Ryng M, Keeri AR, Satała G, Olejarz-Maciej A, Koczurkiewicz P, Drop M, Blicharz K, Piska K, Pękala E, Janiszewska P, Krawczyk M, Walczak M, Chaumont-Dubel S, Bojarski AJ, Marin P, Popik P, Zajdel P. Canale V, et al. Among authors: koczurkiewicz p. Eur J Med Chem. 2020 Dec 15;208:112765. doi: 10.1016/j.ejmech.2020.112765. Epub 2020 Aug 22. Eur J Med Chem. 2020. PMID: 32949963
Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives.
Czopek A, Partyka A, Bucki A, Pawłowski M, Kołaczkowski M, Siwek A, Głuch-Lutwin M, Koczurkiewicz P, Pękala E, Jaromin A, Tyliszczak B, Wesołowska A, Zagórska A. Czopek A, et al. Among authors: koczurkiewicz p. Molecules. 2020 Aug 25;25(17):3868. doi: 10.3390/molecules25173868. Molecules. 2020. PMID: 32854402 Free PMC article.
Novel phosphodiesterases inhibitors from the group of purine-2,6-dione derivatives as potent modulators of airway smooth muscle cell remodelling.
Wójcik-Pszczoła K, Chłoń-Rzepa G, Jankowska A, Ellen E, Świerczek A, Pociecha K, Koczurkiewicz P, Piska K, Gawędzka A, Wyska E, Knapik-Czajka M, Pękala E, Gosens R. Wójcik-Pszczoła K, et al. Among authors: koczurkiewicz p. Eur J Pharmacol. 2019 Dec 15;865:172779. doi: 10.1016/j.ejphar.2019.172779. Epub 2019 Nov 6. Eur J Pharmacol. 2019. PMID: 31705904
High bisphenol A concentrations augment the invasiveness of tumor cells through Snail-1/Cx43/ERRγ-dependent epithelial-mesenchymal transition.
Ryszawy D, Pudełek M, Kochanowski P, Janik-Olchawa N, Bogusz J, Rąpała M, Koczurkiewicz P, Mikołajczyk J, Borek I, Kędracka-Krok S, Karnas E, Zuba-Surma E, Madeja Z, Czyż J. Ryszawy D, et al. Among authors: koczurkiewicz p. Toxicol In Vitro. 2020 Feb;62:104676. doi: 10.1016/j.tiv.2019.104676. Epub 2019 Oct 17. Toxicol In Vitro. 2020. PMID: 31629898
Metabolic stability and its role in the discovery of new chemical entities.
Słoczyńska K, Gunia-Krzyżak A, Koczurkiewicz P, Wójcik-Pszczoła K, Żelaszczyk D, Popiół J, Pękala E. Słoczyńska K, et al. Among authors: koczurkiewicz p. Acta Pharm. 2019 Sep 1;69(3):345-361. doi: 10.2478/acph-2019-0024. Acta Pharm. 2019. PMID: 31259741 Free article. Review.
Discovery of Novel UV-Filters with Favorable Safety Profiles in the 5-Arylideneimidazolidine-2,4-dione Derivatives Group.
Popiół J, Gunia-Krzyżak A, Piska K, Żelaszczyk D, Koczurkiewicz P, Słoczyńska K, Wójcik-Pszczoła K, Krupa A, Kryczyk-Poprawa A, Żesławska E, Nitek W, Żmudzki P, Marona H, Pękala E. Popiół J, et al. Among authors: koczurkiewicz p. Molecules. 2019 Jun 24;24(12):2321. doi: 10.3390/molecules24122321. Molecules. 2019. PMID: 31238526 Free PMC article.
45 results