Paul George AA - Search Results

1

Effect of Conformational Diversity on the Bioactivity of µ-Conotoxin PIIIA Disulfide Isomers.

Paul George AA, Heimer P, Leipold E, Schmitz T, Kaufmann D, Tietze D, Heinemann SH, Imhof D. Paul George AA, et al. Mar Drugs. 2019 Jul 2;17(7):390. doi: 10.3390/md17070390. Mar Drugs. 2019. PMID: 31269696 Free PMC article.

2

Insights into the Folding of Disulfide-Rich μ-Conotoxins.

Paul George AA, Heimer P, Maaß A, Hamaekers J, Hofmann-Apitius M, Biswas A, Imhof D. Paul George AA, et al. ACS Omega. 2018 Oct 31;3(10):12330-12340. doi: 10.1021/acsomega.8b01465. Epub 2018 Oct 1. ACS Omega. 2018. PMID: 30411002 Free PMC article.

3

Coagulation Factor XIIIa Inhibitor Tridegin: On the Role of Disulfide Bonds for Folding, Stability, and Function.

Bäuml CA, Schmitz T, Paul George AA, Sudarsanam M, Hardes K, Steinmetzer T, Holle LA, Wolberg AS, Pötzsch B, Oldenburg J, Biswas A, Imhof D. Bäuml CA, et al. Among authors: paul george aa. J Med Chem. 2019 Apr 11;62(7):3513-3523. doi: 10.1021/acs.jmedchem.8b01982. Epub 2019 Mar 21. J Med Chem. 2019. PMID: 30852892 Free PMC article.

4

Distinct 3-disulfide-bonded isomers of tridegin differentially inhibit coagulation factor XIIIa: The influence of structural stability on bioactivity.

Bäuml CA, Paul George AA, Schmitz T, Sommerfeld P, Pietsch M, Podsiadlowski L, Steinmetzer T, Biswas A, Imhof D. Bäuml CA, et al. Among authors: paul george aa. Eur J Med Chem. 2020 Sep 1;201:112474. doi: 10.1016/j.ejmech.2020.112474. Epub 2020 May 23. Eur J Med Chem. 2020. PMID: 32698061

5

NMR-Based Structural Characterization of a Two-Disulfide-Bonded Analogue of the FXIIIa Inhibitor Tridegin: New Insights into Structure-Activity Relationships.

Schmitz T, Paul George AA, Nubbemeyer B, Bäuml CA, Steinmetzer T, Ohlenschläger O, Biswas A, Imhof D. Schmitz T, et al. Among authors: paul george aa. Int J Mol Sci. 2021 Jan 17;22(2):880. doi: 10.3390/ijms22020880. Int J Mol Sci. 2021. PMID: 33477282 Free PMC article.

6

Structural insights into heme binding to IL-36α proinflammatory cytokine.

Wißbrock A, Goradia NB, Kumar A, Paul George AA, Kühl T, Bellstedt P, Ramachandran R, Hoffmann P, Galler K, Popp J, Neugebauer U, Hampel K, Zimmermann B, Adam S, Wiendl M, Krönke G, Hamza I, Heinemann SH, Frey S, Hueber AJ, Ohlenschläger O, Imhof D. Wißbrock A, et al. Among authors: paul george aa. Sci Rep. 2019 Nov 15;9(1):16893. doi: 10.1038/s41598-019-53231-0. Sci Rep. 2019. PMID: 31729440 Free PMC article.

7

Molecular Insights and Functional Consequences of the Interaction of Heme with Activated Protein C.

Hopp MT, Alhanafi N, Paul George AA, Hamedani NS, Biswas A, Oldenburg J, Pötzsch B, Imhof D. Hopp MT, et al. Among authors: paul george aa. Antioxid Redox Signal. 2021 Jan 1;34(1):32-48. doi: 10.1089/ars.2019.7992. Epub 2020 Aug 20. Antioxid Redox Signal. 2021. PMID: 32705892

8

The molecular basis of transient heme-protein interactions: analysis, concept and implementation.

Wißbrock A, Paul George AA, Brewitz HH, Kühl T, Imhof D. Wißbrock A, et al. Among authors: paul george aa. Biosci Rep. 2019 Jan 30;39(1):BSR20181940. doi: 10.1042/BSR20181940. Print 2019 Jan 31. Biosci Rep. 2019. PMID: 30622148 Free PMC article. Review.

9

Strategies towards Targeting Gαi/s Proteins: Scanning of Protein-Protein Interaction Sites To Overcome Inaccessibility.

Nubbemeyer B, Pepanian A, Paul George AA, Imhof D. Nubbemeyer B, et al. Among authors: paul george aa. ChemMedChem. 2021 Jun 7;16(11):1696-1715. doi: 10.1002/cmdc.202100039. Epub 2021 Mar 22. ChemMedChem. 2021. PMID: 33615736 Free PMC article. Review.

10

Targeting Gαi/s Proteins with Peptidyl Nucleotide Exchange Modulators.

Nubbemeyer B, Paul George AA, Kühl T, Pepanian A, Beck MS, Maghraby R, Shetab Boushehri M, Muehlhaupt M, Pfeil EM, Annala SK, Ammer H, Imhof D, Pei D. Nubbemeyer B, et al. Among authors: paul george aa. ACS Chem Biol. 2022 Feb 18;17(2):463-473. doi: 10.1021/acschembio.1c00929. Epub 2022 Jan 18. ACS Chem Biol. 2022. PMID: 35042325 Free PMC article.

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